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An Alternative Cure: The Adoption and Survival of Bacteriophage Therapy in the USSR, 1922-1955.一种替代疗法:1922年至1955年苏联噬菌体疗法的采用与存续
J Hist Med Allied Sci. 2018 Oct 1;73(4):385-411. doi: 10.1093/jhmas/jry024.
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Front Microbiol. 2018 Jan 11;8:2660. doi: 10.3389/fmicb.2017.02660. eCollection 2017.
3
Phage therapy--history from Twort and d'Herelle through Soviet experience to current approaches.噬菌体疗法——从 Twort 和 d'Herelle 到苏联经验再到当前方法的历史。
Adv Virus Res. 2012;83:3-40. doi: 10.1016/B978-0-12-394438-2.00001-3.
4
Was there a Bacteriological Revolution in late nineteenth-century medicine?19世纪后期的医学是否发生了细菌学革命?
Stud Hist Philos Biol Biomed Sci. 2007 Mar;38(1):20-42. doi: 10.1016/j.shpsc.2006.12.003. Epub 2007 Feb 12.
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In utero detection of T7 phage after systemic administration to pregnant mice.对怀孕小鼠进行全身给药后,在子宫内检测T7噬菌体。
Biotechniques. 2004 Jul;37(1):81-3. doi: 10.2144/04371ST04.

乔治·埃利亚瓦教授与埃利亚瓦噬菌体研究所。

Professor Giorgi Eliava and the Eliava Institute of Bacteriophage.

作者信息

Chanishvili Nina, Myelnikov Dmitriy, Blauvelt Timothy K

机构信息

R&D Department, George Eliava Institute of Bacteriophages, Microbiology and Virology, Tbilisi, Georgia.

Centre for the History of Science, Technology and Medicine (CHSTM)/Division of Medical Education, University of Manchester, United Kingdom.

出版信息

Phage (New Rochelle). 2022 Jun 1;3(2):71-80. doi: 10.1089/phage.2022.0016. Epub 2022 Jun 16.

DOI:10.1089/phage.2022.0016
PMID:36157286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9436386/
Abstract

In the history of medicine little is known about Prof. Giorgi (George) Eliava, who must be recognized as one of the central figures in the story of bacteriophages. Today it may be said without any exaggeration that without the support that Eliava provided to Felix d'Herelle, much of our knowledge about phage therapy would never have been acquired. Eliava played a central role in developing and promoting therapeutic uses of bacteriophages in the Union of Soviet Socialist Republics and beyond, and it was largely due to his efforts-and the institute that he established-that phage therapy survived in Soviet Georgia during the Cold War when it was largely abandoned in the West. Because of his progressive thinking, tireless activities, and close collaborations with many foreign scientists, including d'Herelle, Eliava became a victim of Stalin's regime in 1937, declared an "Enemy of the People" and executed. Most photographs and documents belonging to Eliava were destroyed by the Committee for State Security (), so it is difficult to ascertain many of the details of his life, and his scientific activities are largely unknown. His memory was restored only after the reassessment of the outcomes of the Great Terror and Stalin's regime in later periods. In this article, we bring the remarkable but little-known story of Giorgi Eliava to a wide readership and thus pay tribute to his talent and his dedication to science, and celebrate his contributions to phage research and phage therapy.

摘要

在医学史上,人们对乔治·埃利亚瓦教授所知甚少,而他必须被视为噬菌体研究历程中的核心人物之一。如今可以毫不夸张地说,如果没有埃利亚瓦给予费利克斯·德赫雷尔的支持,我们关于噬菌体疗法的许多知识将永远无法获得。埃利亚瓦在苏联及其他地区开发和推广噬菌体的治疗用途方面发挥了核心作用,很大程度上正是由于他的努力以及他所建立的研究所,噬菌体疗法在冷战期间于苏联格鲁吉亚得以存续,而当时它在西方已基本被摒弃。由于他的进步思想、不懈活动以及与包括德赫雷尔在内的许多外国科学家的密切合作,埃利亚瓦在1937年成为斯大林政权的受害者,被宣布为“人民公敌”并遭处决。属于埃利亚瓦的大多数照片和文件都被国家安全委员会销毁了,因此很难确定他生活中的许多细节,他的科学活动也大多不为人知。只是在后来对大恐怖和斯大林政权的结果进行重新评估之后,他才得以恢复名誉。在本文中,我们向广大读者讲述乔治·埃利亚瓦非凡却鲜为人知的故事,从而致敬他的才华和对科学的奉献,并颂扬他对噬菌体研究和噬菌体疗法的贡献。