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卵巢组织库用于生育力保存和抗绝经激素替代。

Ovarian tissue bank for fertility preservation and anti-menopause hormone replacement.

机构信息

Department of Reproductive Medicine Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

The Assisted Reproduction Department, Yichun Maternal and Child Health Hospital, Yichun, China.

出版信息

Front Endocrinol (Lausanne). 2022 Sep 9;13:950297. doi: 10.3389/fendo.2022.950297. eCollection 2022.

Abstract

Traditional fertility preservation methods such as embryo or oocyte cryopreservation cannot meet the needs of a cancer patient or for personal reasons. The cryopreservation of ovarian tissue can be an alternative and has become a hot spot to preserve fertility or hormone replacement. The freezing of ovarian tissue can be carried out at any time without ovarian hyperstimulation to retrieve follicles. It is an ideal strategy to preserve reproductive function in children, adolescent cancer patients, and patients who are in urgent need of cancer treatment. With the increasing demands of women with premature ovarian failure or in menopause, ovarian tissue transplantation is also an alternative for hormone replacement that can provide physiological doses of hormone levels, which can avoid a series of risks such as thrombosis, breast cancer, or other hormone-dependent tumors, caused by oral hormone replacement. Hence, ovarian tissue banking can be regarded as a mainstream strategy for fertility preservation and anti-menopause hormone replacement in further clinical investigation.

摘要

传统的生育力保存方法,如胚胎或卵母细胞冷冻保存,无法满足癌症患者或个人原因的需求。卵巢组织的冷冻保存可以作为一种替代方法,并且已成为保存生育力或激素替代的热点。卵巢组织的冷冻可以在任何时候进行,而无需卵巢过度刺激以获取卵泡。对于儿童、青少年癌症患者和急需癌症治疗的患者,这是一种保存生殖功能的理想策略。随着卵巢早衰或绝经前妇女的需求不断增加,卵巢组织移植也是激素替代的一种替代方法,它可以提供生理剂量的激素水平,从而避免口服激素替代引起的一系列风险,如血栓形成、乳腺癌或其他激素依赖性肿瘤。因此,卵巢组织库可以被视为进一步临床研究中生育力保存和抗绝经激素替代的主流策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f9b/9506376/be09519568a4/fendo-13-950297-g001.jpg

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