中国首例卵巢组织移植后防止卵巢早衰的妊娠。
First pregnancy in China after ovarian tissue transplantation to prevent premature ovarian insufficiency.
机构信息
Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Beijing Maternal and Child Health Care Hospital, Beijing, China.
出版信息
Climacteric. 2021 Dec;24(6):624-628. doi: 10.1080/13697137.2021.1956453. Epub 2021 Aug 10.
OBJECTIVE
This article reports the first case of pregnancy after frozen-thawed ovarian tissue transplantation to prevent iatrogenic premature ovarian insufficiency in China.
METHODS
Ovarian tissue cryopreservation was performed in a patient with myelodysplastic syndrome (MDS) before multi-agent chemotherapy and hematopoietic stem cell transplantation. Two years later, she showed complete remission from MDS, and six frozen-thawed ovarian tissue strips were transplanted into the peritoneal pocket.
RESULTS
The patient's ovarian activity was restored 3 months after transplantation, and pregnancy occurred spontaneously 27 months after grafting. Until now, the pregnancy has progressed for 30 weeks, and the repeated ultrasound showed normal fetal development.
CONCLUSION
This is the first pregnancy resulting from ovarian tissue cryopreservation and transplantation in China.
目的
本文报告了首例在中国使用冻融卵巢组织移植来预防医源性卵巢早衰的妊娠案例。
方法
一名患有骨髓增生异常综合征（MDS）的患者在接受多药化疗和造血干细胞移植前进行了卵巢组织冷冻保存。两年后，她的 MDS 完全缓解，移植了 6 条冻融卵巢组织条到腹腔口袋中。
结果
移植后 3 个月患者的卵巢功能恢复，移植后 27 个月自然妊娠。至今，妊娠已进展 30 周，重复超声显示胎儿发育正常。
结论
这是中国首例通过卵巢组织冷冻保存和移植获得的妊娠。
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