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2002 年至 2022 年糖尿病及其并发症中 RNA 甲基化的文献计量学分析。

A bibliometric analysis of RNA methylation in diabetes mellitus and its complications from 2002 to 2022.

机构信息

Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.

出版信息

Front Endocrinol (Lausanne). 2022 Sep 8;13:997034. doi: 10.3389/fendo.2022.997034. eCollection 2022.

DOI:10.3389/fendo.2022.997034
PMID:36157472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9492860/
Abstract

BACKGROUND

RNA methylation has emerged as an active research field in diabetes mellitus (DM) and its complications, while few bibliometric analyses have been performed. We aimed to visualize the hotspots and trends using bibliometric analysis to provide a comprehensive and objective overview of the current search state in this field.

METHODS

The articles and reviews regarding RNA methylation in DM and its complications were from the Web of Science Core Collection. A retrospective bibliometric analysis and science mapping was performed using the CiteSpace software to plot the knowledge maps and predict the hotspots and trends.

RESULTS

Three hundred seventy-five qualified records were retrieved. The annual publications gradually increased over the past 20 years. These publications mainly came from 66 countries led by Canada and 423 institutions. Leiter and Sievenpiper were the most productive authors, and Jenkins ranked first in the cited authors. was the most co-cited journal. The most common keywords were "Type 2 diabetes", "cardiovascular disease", "diabetes mellitus", and "n 6 methyladenosine". The extracted keywords mainly clustered in "beta-cell function", "type 2 diabetes", "diabetic nephropathy", "aging", and "n6-methyladenosine". N6-methyladenosine (mA) in DM and its complications were the developing areas of study.

CONCLUSION

Studies on RNA methylation, especially mA modification, are the current hotspots and the future trends in type 2 diabetes (T2D) and diabetic nephropathy (DN), as well as a frontier field for other complications of DM. Strengthening future cooperation and exchange between countries and institutions is strongly advisable to promote research developments in this field.

摘要

背景

RNA 甲基化已成为糖尿病（DM）及其并发症研究的活跃领域，尽管很少进行文献计量分析。我们旨在通过文献计量分析来可视化热点和趋势，为该领域的当前研究状态提供全面和客观的概述。

方法

本研究从 Web of Science 核心合集数据库中检索了有关 DM 及其并发症中 RNA 甲基化的文章和综述。使用 CiteSpace 软件进行回顾性文献计量分析和科学图谱绘制，以绘制知识图谱并预测热点和趋势。

结果

共检索到 375 篇符合条件的记录。过去 20 年来，年度出版物数量逐渐增加。这些出版物主要来自加拿大领导的 66 个国家和 423 个机构。Leiter 和 Sievenpiper 是最具生产力的作者，而 Jenkins 在被引作者中排名第一。是被引频次最高的期刊。最常见的关键词是“2 型糖尿病”、“心血管疾病”、“糖尿病”和“n6 甲基腺苷”。提取的关键词主要聚集在“β细胞功能”、“2 型糖尿病”、“糖尿病肾病”、“衰老”和“n6-甲基腺苷”。DM 及其并发症中的 N6-甲基腺苷（mA）是研究的新兴领域。

结论

RNA 甲基化研究，特别是 mA 修饰，是 2 型糖尿病（T2D）和糖尿病肾病（DN）的当前热点和未来趋势，也是 DM 其他并发症的前沿领域。强烈建议各国和各机构加强未来的合作与交流，以促进该领域的研究进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/172a15c84c91/fendo-13-997034-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/d4a15c63b00b/fendo-13-997034-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/db994b4bb132/fendo-13-997034-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/ade23cf8a296/fendo-13-997034-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/a0c46bba1d74/fendo-13-997034-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/172a15c84c91/fendo-13-997034-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/ea8242a3c398/fendo-13-997034-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/b6ed58416c90/fendo-13-997034-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/21d7482d2db3/fendo-13-997034-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/7bd24f09f78c/fendo-13-997034-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/1ffe40436e2f/fendo-13-997034-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/47fa35419197/fendo-13-997034-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/d4a15c63b00b/fendo-13-997034-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/db994b4bb132/fendo-13-997034-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/ade23cf8a296/fendo-13-997034-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/0d23f4461960/fendo-13-997034-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/a0c46bba1d74/fendo-13-997034-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/921c/9492860/172a15c84c91/fendo-13-997034-g012.jpg

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