淋巴细胞分泌的介质对巨噬细胞功能的影响。
Alterations of macrophage functions by mediators from lymphocytes.
作者信息
Nathan C F, Karnovsky M L, David J R
出版信息
J Exp Med. 1971 Jun 1;133(6):1356-76. doi: 10.1084/jem.133.6.1356.
Abstract
Sensitized lymphocytes were incubated in vitro with the specific antigen Supernatants from these cultures were chromatographed on Sephadex G-100 columns. Supernatant fractions containing MIF, chemotactic factor, and lymphotoxin, but free of antigen and antibody, were incubated with normal peritoneal exudate macrophages. Macrophage adherence, phagocytosis, spreading, motility, and direct hexose monophosphate oxidation were enhanced, while protein synthesis was unaffected. Thus, antigen-stimulated lymphocytes secrete a factor or factors which enhance certain macrophage functions. Implications for models of cellular immunity and cellular hypersensitivity are discussed.
摘要
将致敏淋巴细胞与特异性抗原在体外孵育。这些培养物的上清液在Sephadex G - 100柱上进行层析。含有巨噬细胞移动抑制因子、趋化因子和淋巴毒素但不含抗原和抗体的上清液组分与正常腹膜渗出巨噬细胞一起孵育。巨噬细胞的黏附、吞噬、铺展、运动以及直接的己糖磷酸氧化增强，而蛋白质合成未受影响。因此，抗原刺激的淋巴细胞分泌一种或多种增强某些巨噬细胞功能的因子。文中讨论了其对细胞免疫和细胞超敏反应模型的意义。
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