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菌血症所致肝脓肿及其与结肠癌的关联:菌血症是否为结肠癌的警示信号?

Liver Abscess due to Bacteremia and Its Association with Colonic Carcinoma: Is Bacteremia with an Alert for Colonic Carcinoma?

作者信息

Ota Ikuo, Takahashi Hitoshi, Ono Megumi, Yamamoto Seiki, Kogita Akihiro, Tsuda Hiroshi, Funai Sadao, Shigeoka Hironori, Hiraide Atsushi

机构信息

Department of Emergency Medicine, Nagayama Hospital, Kumatori, Japan.

Department of Surgery, Nagayama Hospital, Kumatori, Japan.

出版信息

Case Rep Gastroenterol. 2022 Aug 19;16(2):488-495. doi: 10.1159/000526158. eCollection 2022 May-Aug.

DOI:10.1159/000526158
PMID:36157604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9459598/
Abstract

Liver abscess caused by some kinds of group such as group has been recognized to associate with colorectal cancer. group with liver abscess has not been received much attention in this point of view. Here, we report the case of a 63-year-old man who developed liver abscess with , which belongs to the group. We confirmed that this case was accompanied by cecal carcinoma by colonoscopy. The tumor was a pathological lead point of intussusception of cecum. On the 26th day, open right hemicolectomy was performed. In this case, bacterial endophthalmitis was a complication due to bacteremia. The patient underwent ophthalmic surgery on the 98th day. Research investigating 16S rRNA of the mucosal colon microbiome reported that the gene was upregulated in patients with colorectal carcinoma. It is recommended that liver abscess with bacteremia should alert the clinician about the risks of carcinoma of the colon and abscess formation in distant organs. We here list the case reports of liver abscess caused by other than group, which was associated with colonic carcinoma, and suggest the need for further research about group.

摘要

由某些菌群(如 菌群)引起的肝脓肿已被认为与结直肠癌有关。从这一角度来看,由 菌群引起的肝脓肿尚未受到太多关注。在此,我们报告一例63岁男性患者,其发生了由属于 菌群的 引起的肝脓肿。通过结肠镜检查,我们确认该病例伴有盲肠癌。该肿瘤是盲肠套叠的病理起始点。在第26天,进行了开放性右半结肠切除术。在该病例中,细菌性眼内炎是菌血症引起的并发症。患者在第98天接受了眼科手术。一项关于结肠黏膜微生物群16S rRNA的研究报告称, 基因在结直肠癌患者中上调。建议伴有 菌血症的肝脓肿应提醒临床医生注意结肠癌和远处器官脓肿形成的风险。我们在此列出了除 菌群外由 引起的与结肠癌相关的肝脓肿病例报告,并建议对 菌群进行进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e321/9459598/05baac761aac/crg-0016-0488-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e321/9459598/5c14310dd238/crg-0016-0488-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e321/9459598/43ee5ed71d50/crg-0016-0488-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e321/9459598/05baac761aac/crg-0016-0488-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e321/9459598/5c14310dd238/crg-0016-0488-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e321/9459598/43ee5ed71d50/crg-0016-0488-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e321/9459598/05baac761aac/crg-0016-0488-g03.jpg

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本文引用的文献

1
Case Report: Subtherapeutic Vancomycin and Meropenem Concentrations due to Augmented Renal Clearance in a Patient With Intracranial Infection Caused by .病例报告:一名颅内感染患者因肾清除率增加导致万古霉素和美罗培南血药浓度低于治疗水平 。 (注:原文中“Caused by.”后面内容缺失)
Front Pharmacol. 2021 Oct 6;12:728075. doi: 10.3389/fphar.2021.728075. eCollection 2021.
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16S rRNA of Mucosal Colon Microbiome and CCL2 Circulating Levels Are Potential Biomarkers in Colorectal Cancer.黏膜结肠微生物组 16S rRNA 和 CCL2 循环水平可能是结直肠癌的生物标志物。
Int J Mol Sci. 2021 Oct 4;22(19):10747. doi: 10.3390/ijms221910747.
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Colon Carcinoma Presenting as Bacteremia and Liver Abscess.
以菌血症和肝脓肿为表现的结肠癌
Gastroenterology Res. 2017 Dec;10(6):376-379. doi: 10.14740/gr884w. Epub 2018 Jan 3.
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Colorectal Cancer Associated with Streptococcus anginosus Bacteremia and Liver Abscesses.与咽峡炎链球菌菌血症和肝脓肿相关的结直肠癌
Case Rep Gastroenterol. 2016 Dec 13;10(3):769-774. doi: 10.1159/000452757. eCollection 2016 Sep-Dec.
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Antimicrobial Therapy for Pyogenic Liver Abscess Secondary to Streptococcus intermedius Bacteremia.中间型链球菌菌血症继发化脓性肝脓肿的抗菌治疗
Am J Ther. 2017 Nov/Dec;24(6):e770-e771. doi: 10.1097/MJT.0000000000000537.
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Antibiotic susceptibility of periodontal Streptococcus constellatus and Streptococcus intermedius clinical isolates.牙周星座链球菌和中间链球菌临床分离株的抗生素敏感性
J Periodontol. 2014 Dec;85(12):1792-8. doi: 10.1902/jop.2014.130291.
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Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59.鉴定中间型链球菌毒素间链溶素与膜受体人补体调节蛋白CD59的高亲和力结合位点。
Mol Immunol. 2009 Apr;46(7):1561-7. doi: 10.1016/j.molimm.2009.01.003. Epub 2009 Feb 6.
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Streptococcus intermedius liver abscesses and colon cancer: a case report.中间型链球菌肝脓肿与结肠癌:一例报告
West Indian Med J. 2005 Oct;54(5):341-2. doi: 10.1590/s0043-31442005000500014.
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Liver abscesses caused by Streptococcus milleri: an uncommon presenting sign of silent colonic cancer.米勒链球菌引起的肝脓肿:一种隐匿性结肠癌不常见的表现体征。
Isr Med Assoc J. 2003 Mar;5(3):206-7.
10
Streptococcus intermedius, Streptococcus constellatus, and Streptococcus anginosus ("Streptococcus milleri group") are of different clinical importance and are not equally associated with abscess.中间型链球菌、星座链球菌和咽峡炎链球菌(“米勒链球菌组”)具有不同的临床重要性,且与脓肿的关联程度并不相同。
Clin Infect Dis. 2001 May 15;32(10):1511-5. doi: 10.1086/320163. Epub 2001 Apr 20.