• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A treasure from a barren island: the discovery of rapamycin.

作者信息

Hobby Gerren, Clark Rebecca, Woywodt Alexander

机构信息

Department of Nephrology, NEA Baptist Clinic, Jonesboro, AR, USA.

Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, Lancashire, UK.

出版信息

Clin Kidney J. 2022 Apr 29;15(10):1971-1972. doi: 10.1093/ckj/sfac116. eCollection 2022 Oct.

DOI:10.1093/ckj/sfac116
PMID:36158154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9494524/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb8/9494524/ec5740125c36/sfac116fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb8/9494524/276ca8b3a4ae/sfac116fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb8/9494524/ec5740125c36/sfac116fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb8/9494524/276ca8b3a4ae/sfac116fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb8/9494524/ec5740125c36/sfac116fig2.jpg

相似文献

1
A treasure from a barren island: the discovery of rapamycin.来自荒岛的宝藏：雷帕霉素的发现。
Clin Kidney J. 2022 Apr 29;15(10):1971-1972. doi: 10.1093/ckj/sfac116. eCollection 2022 Oct.
2
Unexplored deep sea habitats in active volcanic Barren Island, Andaman and Nicobar Islands are sources of novel halophilic eubacteria.在安达曼和尼科巴群岛的巴尔雷恩岛上，未被探索的深海热液喷口是新型嗜盐真细菌的来源。
Infect Genet Evol. 2018 Nov;65:1-5. doi: 10.1016/j.meegid.2018.07.008. Epub 2018 Jul 6.
3
Subpopulation structure of caribou (Rangifer tarandus L.) in arctic and subarctic Canada.加拿大北极和亚北极地区驯鹿（Rangifer tarandus L.）的亚群结构。
Ecol Appl. 2011 Sep;21(6):2334-48. doi: 10.1890/10-1410.1.
4
Mitotic chromosome condensation requires Brn1p, the yeast homologue of Barren.有丝分裂染色体凝聚需要Brn1p，它是Barren在酵母中的同源物。
Mol Biol Cell. 2000 Apr;11(4):1293-304. doi: 10.1091/mbc.11.4.1293.
5
barren inflorescence2 regulates axillary meristem development in the maize inflorescence.不育花序2调控玉米花序中腋生分生组织的发育。
Development. 2001 Aug;128(15):2881-91. doi: 10.1242/dev.128.15.2881.
6
Immunity in barren and enriched housed pigs differing in baseline cortisol concentration.基础皮质醇浓度不同的贫瘠饲养和丰富饲养猪的免疫力。
Physiol Behav. 2000;71(3-4):217-23. doi: 10.1016/s0031-9384(00)00336-x.
7
Effects of environmental enrichment on behavioral responses to novelty, learning, and memory, and the circadian rhythm in cortisol in growing pigs.环境富集对生长猪对新奇事物的行为反应、学习和记忆以及皮质醇昼夜节律的影响。
Physiol Behav. 2000 Feb;68(4):571-8. doi: 10.1016/s0031-9384(99)00212-7.
8
Morpho-functional studies regarding the fertility prognosis of mares suffering from equine endometrosis.马属动物子宫内膜异位症对母马生育力预后的形态功能研究。
Theriogenology. 2011 Oct 15;76(7):1326-36. doi: 10.1016/j.theriogenology.2011.06.001.
9
Impact of preweaning stress on long-term neurobehavioral outcomes in Sprague-Dawley rats: Differential effects of barren cage rearing, pup isolation, and the combination.断乳前应激对 Sprague-Dawley 大鼠长期神经行为结局的影响：空旷鼠笼饲养、离乳仔隔离和二者联合的不同影响。
Neurotoxicol Teratol. 2021 Mar-Apr;84:106956. doi: 10.1016/j.ntt.2021.106956. Epub 2021 Jan 29.
10
Artificial root exudates restore microbial functioning in a metal contaminated, barren, inactive soil.人工根渗出物可恢复受金属污染、贫瘠和非活性土壤中的微生物功能。
Environ Pollut. 2022 Nov 1;312:120007. doi: 10.1016/j.envpol.2022.120007. Epub 2022 Aug 20.

引用本文的文献

1
[Inception of the coronary stent: a story of successful collaboration between innovative scientists and the biotechnology industry].[冠状动脉支架的起源：创新科学家与生物技术产业成功合作的故事]
REC Interv Cardiol. 2024 May 20;6(4):321-331. doi: 10.24875/RECIC.M24000463. eCollection 2024 Oct-Dec.
2
Chemical Probes for Studying the Eukaryotic Translation Initiation Factor 4E (eIF4E)-Regulated Translatome in Cancer.用于研究癌症中真核翻译起始因子4E（eIF4E）调控的翻译组的化学探针
ACS Pharmacol Transl Sci. 2025 Feb 17;8(3):621-635. doi: 10.1021/acsptsci.4c00674. eCollection 2025 Mar 14.
3
mTOR hyperactivity and amplification as targets for personalized treatments in malignancies.

本文引用的文献

1
Surendra Nath Sehgal: A pioneer in rapamycin discovery.苏伦德拉·纳特·塞加尔：雷帕霉素发现的先驱。
Indian J Cancer. 2017 Oct-Dec;54(4):697-698. doi: 10.4103/ijc.IJC_84_18.
2
Rapamycin: one drug, many effects.雷帕霉素：一种药物，多种效应。
Cell Metab. 2014 Mar 4;19(3):373-9. doi: 10.1016/j.cmet.2014.01.001. Epub 2014 Feb 6.
3
Sirolimus: its discovery, biological properties, and mechanism of action.西罗莫司：其发现、生物学特性及作用机制。
mTOR 过度活跃和扩增作为恶性肿瘤个体化治疗的靶点。
Pathol Oncol Res. 2024 Mar 7;30:1611643. doi: 10.3389/pore.2024.1611643. eCollection 2024.
4
A New Hypothesis Describing the Pathogenesis of Oral Mucosal Injury Associated with the Mammalian Target of Rapamycin (mTOR) Inhibitors.一种描述与雷帕霉素哺乳动物靶点（mTOR）抑制剂相关的口腔黏膜损伤发病机制的新假说。
Cancers (Basel). 2023 Dec 22;16(1):68. doi: 10.3390/cancers16010068.
5
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease.mTOR（哺乳动物雷帕霉素靶蛋白）信号通路在人类健康和疾病中的多方面作用。
Signal Transduct Target Ther. 2023 Oct 2;8(1):375. doi: 10.1038/s41392-023-01608-z.
6
The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on β-Thalassemia and Other Hemoglobinopathies.西罗莫司（雷帕霉素）的漫长科学之旅：从复活节岛（拉帕努伊岛）的土壤到β地中海贫血及其他血红蛋白病的应用研究与临床试验
Biology (Basel). 2023 Sep 2;12(9):1202. doi: 10.3390/biology12091202.
Transplant Proc. 2003 May;35(3 Suppl):7S-14S. doi: 10.1016/s0041-1345(03)00211-2.
4
History of the discovery of cyclosporin and of its early pharmacological development.环孢素的发现历程及其早期药理学发展历程。
Wien Klin Wochenschr. 2002 Jun 28;114(12):433-7.
5
Rapamycin's resurrection: a new way to target the cancer cell cycle.雷帕霉素的复兴：一种靶向癌细胞周期的新方法。
J Natl Cancer Inst. 2001 Oct 17;93(20):1517-9. doi: 10.1093/jnci/93.20.1517.
6
Sirolimus: a new promising immunosuppressive drug. Towards a rationale for its use in renal transplantation.西罗莫司：一种有前景的新型免疫抑制药物。探讨其在肾移植中应用的理论依据。
Nephrol Dial Transplant. 2001 Jan;16(1):18-20. doi: 10.1093/ndt/16.1.18.
7
Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis.从筑波链霉菌中分离出的新型免疫抑制剂FK-506的发现。
Transplant Proc. 1987 Oct;19(5 Suppl 6):4-8.