雷帕霉素：一种药物，多种效应。
Rapamycin: one drug, many effects.
作者信息
Li Jing, Kim Sang Gyun, Blenis John
机构信息
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
出版信息
Cell Metab. 2014 Mar 4;19(3):373-9. doi: 10.1016/j.cmet.2014.01.001. Epub 2014 Feb 6.
Abstract
The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of cell growth and metabolism. Deregulation of the mTOR pathway has been implicated in a number of human diseases such as cancer, diabetes, obesity, neurological diseases, and genetic disorders. Rapamycin, a specific inhibitor of mTOR, has been shown to be useful in the treatment of certain diseases. Here we discuss its mechanism of action and highlight recent findings regarding the effects and limitations of rapamycin monotherapy and the potential utility of combination therapy with rapamycin.
摘要
雷帕霉素的哺乳动物靶点（mTOR）信号通路是细胞生长和代谢的主要调节因子。mTOR通路的失调与多种人类疾病有关，如癌症、糖尿病、肥胖症、神经疾病和遗传疾病。雷帕霉素是mTOR的特异性抑制剂，已被证明对某些疾病的治疗有效。在此，我们讨论其作用机制，并重点介绍关于雷帕霉素单一疗法的效果和局限性以及雷帕霉素联合疗法的潜在效用的最新研究结果。
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