Liu Zhican, Peng Yiqun, Zhao Wenjiao, Zhu Yunlong, Wu Mingxin, Huang Haobo, Peng Ke, Zhang Lingling, Chen Sihao, Peng Xin, Li Na, Zhang Hui, Zhou Yuying, Chen Yongliang, Xiao Sha, Fan Jie, Zeng Jianping
Department of Cardiology, Xiangtan Central Hospital, Xiangtan, China.
Graduate Collaborative Training Base of Xiangtan Central Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Front Cardiovasc Med. 2022 Sep 8;9:967780. doi: 10.3389/fcvm.2022.967780. eCollection 2022.
High body mass index increases the risk of heart failure morbidity and mortality. It is unclear whether a high body mass index is associated with prognosis in patients with heart failure with mildly reduced left ventricular ejection fraction (HFmrEF). We retrospectively analyzed the effect of a high body mass index on the prognosis of patients with HFmrEF.
We investigated the association between body mass index and cardiovascular death (death from any cardiovascular mechanism) in 1,691 HFmrEF patients (mean age, 68 years; 35% female) in Xiangtan Central Hospital. Using Cox proportional hazards models, body mass index was assessed as a continuous and a categorical variable.
Cardiovascular death occurred in 133 patients (82 males and 51 females) after 1 year of follow-up. After adjustment for established risk factors, there was a 7.5% increase in the risk of cardiovascular death for females for each increment of 1 in BMI. In contrast, changes in male body mass index were not significantly associated with cardiovascular death ( = 0.097). Obese subjects had a 1.8-fold increased risk of cardiovascular death compared with subjects with a normal body mass index. The hazard ratio for females was 2.163 (95% confidence interval: 1.150-4.066). Obesity was not significantly associated with cardiovascular death in males ( = 0.085).
An increased body mass index is associated with an increased risk of cardiovascular death in patients with HFmrEF; however, this risk was mainly associated with female patients with HFmrEF and less with male patients with HFmrEF.
高体重指数会增加心力衰竭发病和死亡的风险。目前尚不清楚高体重指数与轻度左心室射血分数降低的心力衰竭（HFmrEF）患者的预后是否相关。我们回顾性分析了高体重指数对HFmrEF患者预后的影响。
我们调查了湘潭市中心医院1691例HFmrEF患者（平均年龄68岁；35%为女性）的体重指数与心血管死亡（任何心血管机制导致的死亡）之间的关联。使用Cox比例风险模型，将体重指数评估为连续变量和分类变量。
随访1年后，133例患者（82例男性和51例女性）发生心血管死亡。在对既定风险因素进行调整后，女性体重指数每增加1，心血管死亡风险增加7.5%。相比之下，男性体重指数的变化与心血管死亡无显著关联（P = 0.097）。与正常体重指数的受试者相比，肥胖受试者的心血管死亡风险增加了1.8倍。女性的风险比为2.163（95%置信区间：1.150 - 4.066）。肥胖与男性心血管死亡无显著关联（P = 0.085）。
体重指数升高与HFmrEF患者心血管死亡风险增加相关；然而，这种风险主要与女性HFmrEF患者相关，而与男性HFmrEF患者的相关性较小。
