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新冠病毒感染中的空气泄漏

Air leaks in COVID-19.

作者信息

Juneja Deven, Kataria Sahil, Singh Omender

机构信息

Institute of Critical Care Medicine, Max Super Speciality Hospital, Saket, New Delhi 110017, India.

出版信息

World J Virol. 2022 Jul 25;11(4):176-185. doi: 10.5501/wjv.v11.i4.176.

Abstract

Coronavirus disease 2019 (COVID-19) continues to create havoc and may present with myriad complications involving many organ systems. However, the respiratory system bears the maximum brunt of the disease and continues to be most commonly affected. There is a high incidence of air leaks in patients with COVID-19, leading to acute worsening of clinical condition. The air leaks may develop independently of the severity of disease or positive pressure ventilation and even in the absence of any traditional risk factors like smoking and un-derlying lung disease. The exact pathophysiology of air leaks with COVID-19 remains unclear, but multiple factors may play a role in their development. A significant proportion of air leaks may be asymptomatic; hence, a high index of suspicion should be exercised for enabling early diagnosis to prevent further deterioration as it is associated with high morbidity and mortality. These air leaks may even develop weeks to months after the disease onset, leading to acute deterioration in the post-COVID period. Conservative management with close monitoring may suffice for many patients but most of the patients with pneumothorax may require intercostal drainage with only a few requiring surgical interventions for persistent air leaks.

摘要

2019年冠状病毒病(COVID-19)持续肆虐,可能会出现涉及多个器官系统的众多并发症。然而,呼吸系统首当其冲,仍然是最常受影响的部位。COVID-19患者发生气胸的几率很高,会导致临床状况急剧恶化。气胸可能独立于疾病严重程度或正压通气而发生,甚至在没有吸烟和潜在肺部疾病等任何传统危险因素的情况下也会出现。COVID-19并发气胸的确切病理生理机制尚不清楚,但多种因素可能在其发生过程中起作用。相当一部分气胸可能没有症状;因此,应保持高度警惕以便早期诊断,防止病情进一步恶化,因为其与高发病率和死亡率相关。这些气胸甚至可能在疾病发作数周或数月后出现,导致COVID-19康复期病情急性恶化。对于许多患者来说,密切监测下的保守治疗可能就足够了,但大多数气胸患者可能需要肋间引流,只有少数持续性气胸患者需要手术干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88b6/9372787/ccbc2a36bd0d/WJV-11-176-g001.jpg

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