Castro-Vázquez A, Gómez E, De Carli D N, Rosner J M
J Endocrinol. 1976 Jan;68(1):121-6. doi: 10.1677/joe.0.0680121.
The effect of doses of estradiol ranging from 0-0125 to 1-6 mug on the uterine weight of the spayed rat was studied 24 h after a single s.c. injection of the hormone. The lowest dose inducing a significant increase in uterine weight was 0-32 mug. When histamine dihydrochloride (50 mg) was simultaneously injected with the hormone, the effect of small doses of oestradiol (0-0125--0-2 mug) was significantly increased. When oestradiol and histamine were administered for 3 successive days, the uterine weight of animals receiving 0-0125 mug oestradiol, if compared with untreated controls, was increased only in the histamine-treated group. When 0-05 mug oestradiol was administered histamine did not modify the increase already produced by the hormone. Spermidine and burimamide, two substances structurally related to histamine, increased [3H]oestradiol uptake by the spayed rat uterus. The latter (an antihistamine drug acting on H2-receptors) as well as pyrathiazine (a histamine releaser having antihistamine properties) decreased the effect of histamine on oestradiol uptake whereas diphenhydramine (an antihistamine drug blocking H1-receptors) did not modify it. Pyrathiazine was itself able to diminish oestradiol uptake.
研究了单次皮下注射激素24小时后，剂量范围为0.0125至1.6微克的雌二醇对去卵巢大鼠子宫重量的影响。引起子宫重量显著增加的最低剂量为0.32微克。当与激素同时注射盐酸组胺（50毫克）时，小剂量雌二醇（0.0125 - 0.2微克）的作用显著增强。当雌二醇和组胺连续给药3天时，接受0.0125微克雌二醇的动物，与未处理的对照组相比，仅在组胺处理组中子宫重量增加。当给予0.05微克雌二醇时，组胺不会改变该激素已产生的增加作用。亚精胺和布立马胺这两种与组胺结构相关的物质，增加了去卵巢大鼠子宫对[³H]雌二醇的摄取。后者（一种作用于H₂受体的抗组胺药）以及吡拉西嗪（一种具有抗组胺特性的组胺释放剂）降低了组胺对雌二醇摄取的作用，而苯海拉明（一种阻断H₁受体的抗组胺药）则没有改变这种作用。吡拉西嗪本身能够减少雌二醇的摄取。
