Ko Hae-Jin, Cho Yoon Jeong, Kim Kyoung-Kon, Kang Jee-Hyun, Kim Young-Sang, Haam Ji-Hee, Hur Yang-Im, Choi Hye-In, Lee Kyu Rae, Park Jung Ha, Cho Soo Hyun, Kim Jong-Koo, Lee Taesic, Seo Myung-Jae, Yoon Yeong Sook, Seo Yoobin, Nam Ga Eun, Kim Sun Hyun
Department of Family Medicine, School of Medicine, Kyungpook National University Hospital, Daegu, South Korea.
Department Family Medicine, Daegu Catholic University School of Medicine, Daegu, South Korea.
Front Med (Lausanne). 2022 Sep 7;9:951793. doi: 10.3389/fmed.2022.951793. eCollection 2022.
This study using multi-center health examination data from Korean adults was conducted to confirm changes in weight, and their related cardiometabolic parameters, before and after strengthening of social distancing regulations.
A retrospective cohort study was conducted using health check-up data from 13 university hospitals. The study period was from January 2018 to July 2020. To examine the effect of systematic social distancing measures, participants who underwent a health check-up (Visit 3) between July 2020 and July 2021 (during full scale social distancing), and had undergone two previous health check-ups (Visits 1 and 2) between January 2018 and June 2020 (before social distancing), were selected. In total, data from 7,875 participants were analyzed. Linear mixed-effect models were used to calculate estimates of anthropometric indices and metabolic markers measured on Visits 2 and 3, compared with measurements from Visit 1.
There were no significant differences in body weight, body mass index, waist circumference, and body composition on Visit 3 than on Visits 1 and 2. However, the odds of metabolic syndrome and its components, including hypertension, high glucose, diabetes, hypercholesterolemia, hypertriglyceridemia, hyper-non-high-density lipoprotein cholesterolemia, and dyslipidemia were significantly higher on Visit 3 than on Visits 1 and 2. The increase in metabolic complications was marked, particularly in relatively young adults who visited health check-up centers located in the capital area.
Metabolic syndrome and its components were significantly worse after high level social distancing, although there were no significant increases in anthropometric indices and body fat levels. Healthcare providers need to prevent and manage worsening of metabolic parameters in subpopulations prone to be more sedentary and eat unhealthy food during the COVID-19 pandemic and associated social distancing measures.
本研究利用韩国成年人的多中心健康检查数据，旨在确认加强社交距离规定前后体重及其相关心脏代谢参数的变化。
采用回顾性队列研究，使用来自13所大学医院的健康检查数据。研究期间为2018年1月至2020年7月。为了检验系统性社交距离措施的效果，选取了在2020年7月至2021年7月（全面社交距离期间）进行健康检查（第3次就诊），且在2018年1月至2020年6月（社交距离实施前）曾进行过两次健康检查（第1次和第2次就诊）的参与者。总共分析了7875名参与者的数据。使用线性混合效应模型计算第2次和第3次就诊时测量的人体测量指标和代谢标志物的估计值，并与第1次就诊时的测量值进行比较。
第3次就诊时的体重、体重指数、腰围和身体成分与第1次和第2次就诊相比无显著差异。然而，第3次就诊时代谢综合征及其组成部分（包括高血压、高血糖、糖尿病、高胆固醇血症、高甘油三酯血症、高非高密度脂蛋白胆固醇血症和血脂异常）的几率显著高于第1次和第2次就诊。代谢并发症的增加很明显，尤其是在首都地区健康检查中心就诊的相对年轻的成年人中。
尽管人体测量指标和体脂水平没有显著增加，但在高度社交距离之后，代谢综合征及其组成部分明显恶化。医疗保健提供者需要预防和管理在COVID-19大流行及相关社交距离措施期间，更容易久坐不动和饮食不健康的亚人群中代谢参数的恶化。
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