Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Department of Health Sciences, Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Clin J Am Soc Nephrol. 2022 Oct;17(10):1506-1514. doi: 10.2215/CJN.05560522.
To date, employment figures of kidney transplant recipients in Europe are inconsistent. Additionally, little is known about work functioning of employed kidney transplant recipients and work functioning trajectories before and after transplantation.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data from the ongoing TransplantLines Biobank and Cohort study and from community-dwelling employed adults were used. Health-related work functioning of kidney transplant recipients was assessed with the Work Role Functioning Questionnaire 2.0 and compared with potential kidney donors and community-dwelling employed adults.
We included 668 kidney transplant recipients of working age (59% men, age 51±11 years) at median 3 (interquartile range, 2-10) years after transplantation, 246 potential kidney donors of working age (43% men, age 53±9 years), and 553 community-dwelling employed adults (70% men, age 45±11 years). The proportion of employed kidney transplant recipients was lower compared with potential kidney donors (56% versus 79%). If employed, the work functioning score of kidney transplant recipients was slightly lower compared with employed potential kidney donors yet higher compared with community-dwelling employed adults (medians 91 [interquartile range, 76-98], 94 [interquartile range, 85-99], and 88 [interquartile range, 79-95], respectively). Backward linear regression analyses revealed that lower educational level, having a kidney from a deceased donor, presence of tingling or numbness of hands or feet, presence of concentration/memory problems, presence of anxiety, and presence of severe fatigue were independently associated with lower work functioning among kidney transplant recipients. Additional subgroup analyses showed that work functioning scores were lower before transplantation than at 12 months after transplantation (83 [interquartile range, 66-93] versus 92 [interquartile range, 88-98], respectively; =0.002).
Stable employed kidney transplant recipients report to function well at work. In addition, this study shows that self-reported work functioning is higher after successful kidney transplantation compared with before transplantation.
TransplantLines Biobank and Cohort study, NCT03272841 PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_09_26_CJN05560522.mp3.
迄今为止，欧洲肾移植受者的就业数据并不一致。此外，人们对就业肾移植受者的工作功能以及移植前后的工作功能轨迹知之甚少。
设计、地点、参与者和测量方法：本研究使用了正在进行的 TransplantLines 生物库和队列研究的数据以及社区居住的就业成年人的数据。使用工作角色功能问卷 2.0 评估肾移植受者的健康相关工作功能，并将其与潜在的肾供者和社区居住的就业成年人进行比较。
我们纳入了 668 名处于工作年龄（59%为男性，年龄 51±11 岁）的肾移植受者，他们在中位数为 3（四分位距，2-10）年时接受了移植，246 名处于工作年龄的潜在肾供者（43%为男性，年龄 53±9 岁），以及 553 名社区居住的就业成年人（70%为男性，年龄 45±11 岁）。与潜在的肾供者相比，就业肾移植受者的比例较低（56%对 79%）。如果就业，肾移植受者的工作功能评分略低于就业的潜在肾供者，但高于社区居住的就业成年人（中位数分别为 91[四分位距，76-98]、94[四分位距，85-99]和 88[四分位距，79-95]）。向后线性回归分析显示，较低的教育水平、使用已故供者的肾脏、手或脚刺痛或麻木、注意力/记忆问题、焦虑和严重疲劳与肾移植受者较低的工作功能相关。进一步的亚组分析显示，工作功能评分在移植前低于移植后 12 个月（83[四分位距，66-93]对 92[四分位距，88-98]；=0.002）。
稳定就业的肾移植受者报告工作功能良好。此外，本研究表明，与移植前相比，成功肾移植后自我报告的工作功能更高。
TransplantLines 生物库和队列研究，NCT03272841 PODCAST：本文包含一个播客，网址为 https://www.asn-online.org/media/podcast/CJASN/2022_09_26_CJN05560522.mp3。
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