Long Tian, Liu Liang
Department of Clinical Nutrition, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei 435000, China.
Appl Bionics Biomech. 2022 Sep 17;2022:5658423. doi: 10.1155/2022/5658423. eCollection 2022.
As the final metabolite of purine metabolism, uric acid is critically associated with human health. The serum uric acid level is regulated by diet and the metabolic capacity of the human body. The impaired control of uric acid metabolism and excretion is associated with the increased level of serum uric acid, which ultimately results in hyperuricemia. Hyperuricemia is the "fourth-highest" after hypertension, hyperglycemia, and hyperlipidemia. With progress made in the relationship between diet and hyperuricemia, different dietary patterns and lifestyles have been discussed, such as exercise, the amount intake of meat, seafood, supplements with omega-3 fatty acids, sugar-sweetened soft drinks and energy drinks, and lower-fat-containing foods as well as drinking beer, wine, and spirits in the present article. This study demonstrated that a lower risk of hyperuricemia is substantially correlated with higher baseline adherence to MeDiet, and plant polyphenols can combat hyperuricemia by blocking xanthine oxidase.
作为嘌呤代谢的终末代谢产物，尿酸与人类健康密切相关。血清尿酸水平受饮食和人体代谢能力的调节。尿酸代谢和排泄控制受损与血清尿酸水平升高有关，最终导致高尿酸血症。高尿酸血症是继高血压、高血糖和高脂血症之后的“第四高”。随着饮食与高尿酸血症关系研究的进展，人们讨论了不同的饮食模式和生活方式，如运动、肉类摄入量、海鲜、补充ω-3脂肪酸、含糖软饮料和能量饮料、低脂食物以及饮用啤酒、葡萄酒和烈酒等。本研究表明，高尿酸血症风险较低与地中海饮食（MeDiet）基线依从性较高显著相关，植物多酚可通过抑制黄嘌呤氧化酶来对抗高尿酸血症。
