Department of Preventive Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
Department of Preventive Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
Semin Arthritis Rheum. 2014 Apr;43(5):654-61. doi: 10.1016/j.semarthrit.2013.10.008. Epub 2013 Oct 29.
The clinical implication of sugar-sweetened soft drinks on the risk of hyperuricemia has increased, especially in Western population studies. The aim of this study is to clarify the association between sugar-sweetened soft drinks and fruit drinks made from oranges and apples and the risk of hyperuricemia in the Korean Multi-Rural Communities Cohort.
A total of 9400 subjects were enrolled in the Korean Multi-Rural Communities Cohort Study, and a cross-sectional analysis was performed. Five quintiles (Q1-Q5) according to consumption of soft drinks and other fruit/fruit juices were classified and then categorized into three groups (Q1-Q3, Q4, and Q5) to assess the risk of hyperuricemia. Information on dietary intake was collected by well-trained interviewers using validated food frequency questionnaires.
Higher consumption of sugar-sweetened soft drinks (Q5) increased the risk of hyperuricemia in males (adjusted OR = 1.35, 95% CI: 1.07-1.71) with a linear trend (p for trend = 0.01) and in females (adjusted OR = 1.40, 95% CI: 1.03-1.90) with no linear trend (p for trend = 0.09), compared to lower consumption (Q1-Q3). However, there were no significant differences of serum uric acid level according to the three categories of soft drink consumption, Q1-Q3, Q3, and Q5, in males (p = 0.21) or in females (p = 0.16), whereas all subjects showed statistical significance of serum uric acid level within the categories (p < 0.001). Estimated amount of soft drink intake was associated with serum uric acid level in males (β = 0.001; p = 0.01) but not in females (β = 0.0005; p = 0.10).
Higher consumption of sugar-sweetened soft drinks increased the risk of hyperuricemia in the Korean population, showing a differential linear trend for hyperuricemia according to gender.
含糖软饮料对高尿酸血症风险的临床意义日益增加，尤其是在西方人群研究中。本研究旨在阐明含糖软饮料和橙汁、苹果汁等水果饮料与韩国多农村社区队列人群高尿酸血症风险之间的关系。
共纳入 9400 名受试者参加韩国多农村社区队列研究，并进行横断面分析。根据软饮料和其他水果/果汁的摄入量将受试者分为五组（Q1-Q5），然后分为三组（Q1-Q3、Q4 和 Q5）评估高尿酸血症的风险。通过经过良好培训的访谈员使用经过验证的食物频率问卷收集饮食摄入信息。
男性中，含糖软饮料（Q5）摄入较高者患高尿酸血症的风险增加（调整后的 OR = 1.35，95%CI：1.07-1.71），呈线性趋势（趋势检验 p = 0.01），女性中，含糖软饮料（Q5）摄入较高者患高尿酸血症的风险也增加（调整后的 OR = 1.40，95%CI：1.03-1.90），但无线性趋势（趋势检验 p = 0.09），与摄入较低者（Q1-Q3）相比。然而，在男性（p = 0.21）或女性（p = 0.16）中，根据软饮料摄入的三个类别（Q1-Q3、Q3 和 Q5），血清尿酸水平无显著差异，而所有受试者在这些类别中均显示出血清尿酸水平的统计学意义（p<0.001）。软饮料摄入量的估计值与男性的血清尿酸水平相关（β=0.001；p=0.01），但与女性无关（β=0.0005；p=0.10）。
在韩国人群中，含糖软饮料的摄入量较高与高尿酸血症风险增加相关，且高尿酸血症的线性趋势存在性别差异。
