Columbia University Irving Medical Center, Division of Digestive and Liver Diseases and the Columbia Mailman School of Public Health, New York, NY.
David Geffen School of Medicine at UCLA, Vatche and Tamar Manoukian Division of Digestive Diseases and the G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, CA, US.
Curr Opin Gastroenterol. 2022 Nov 1;38(6):555-561. doi: 10.1097/MOG.0000000000000876. Epub 2022 Sep 9.
PURPOSE OF REVIEW: A large and growing number of patients have persistent gastrointestinal symptoms that they attribute to COVID-19. SARS-CoV-2, the virus that causes COVID-19, replicates within the gut and acute COVID-19 is associated with alteration of the gut microbiome. This article reviews recent observational data related to gastrointestinal symptoms in 'long COVID' and discusses pathophysiologic mechanisms that might explain persistent post-COVID gastrointestinal symptoms. RECENT FINDINGS: Gastrointestinal symptoms are present in half of the patients with acute COVID-19, persist 6 months after COVID-19 in 10-25% of patients, and are rated as the most bothersome symptom in 11% of all patients. These symptoms include heartburn, constipation, diarrhoea and abdominal pain and decline in prevalence with the passage of time. Long COVID gastrointestinal symptoms are associated with mental health symptoms (anxiety and depression) that predate COVID-19 and also with mental health symptoms that are concurrent, after recovery from COVID-19. The cause of long COVID gastrointestinal symptoms is unknown and hypotheses include the SARS-CoV-2 virus itself, which infects the gastrointestinal tract; COVID-19, which can be accompanied by gut microbiome changes, a profound systemic inflammatory response and critical illness; and/or effects of pandemic stress on gastrointestinal function and symptom perception, which may be unrelated to either SARS-CoV-2 or to COVID-19. SUMMARY: New, persistent gastrointestinal symptoms are commonly reported after recovery from COVID-19. The pathophysiology of these symptoms is unknown but likely to be multifactorial.
目的综述:越来越多的患者出现持续性胃肠道症状,他们将这些症状归因于 COVID-19。导致 COVID-19 的 SARS-CoV-2 病毒在肠道内复制,急性 COVID-19 与肠道微生物组的改变有关。本文综述了与“长新冠”胃肠道症状相关的最新观察性数据,并讨论了可能解释持续性新冠后胃肠道症状的病理生理机制。
最近的发现:半数急性 COVID-19 患者存在胃肠道症状,10-25%的患者在 COVID-19 后 6 个月仍存在这些症状,11%的患者将这些症状评为最困扰的症状。这些症状包括烧心、便秘、腹泻和腹痛,且随着时间的推移其患病率下降。长新冠胃肠道症状与 COVID-19 之前存在的心理健康症状(焦虑和抑郁)以及 COVID-19 康复后同时存在的心理健康症状相关。长新冠胃肠道症状的原因尚不清楚,假设包括感染肠道的 SARS-CoV-2 病毒;可能伴有肠道微生物组变化、全身性炎症反应和危重病的 COVID-19;以及/或大流行压力对胃肠道功能和症状感知的影响,这些影响可能与 SARS-CoV-2 或 COVID-19 无关。
总结:在 COVID-19 康复后,新的持续性胃肠道症状通常会被报告。这些症状的病理生理学尚不清楚,但可能是多因素的。
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