长新冠的沉默综合征与科学知识鸿沟：叙事性综述。

The Silent Syndrome of Long COVID and Gaps in Scientific Knowledge: A Narrative Review.

机构信息

Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.

Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belém 66075-110, Brazil.

出版信息

Viruses. 2024 Aug 5;16(8):1256. doi: 10.3390/v16081256.

DOI:10.3390/v16081256

PMID:39205230

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11359800/

Abstract

COVID-19 is still a major public health concern, mainly due to the persistence of symptoms or the appearance of new symptoms. To date, more than 200 symptoms of long COVID (LC) have been described. The present review describes and maps its relevant clinical characteristics, pathophysiology, epidemiology, and genetic and nongenetic risk factors. Given the currently available evidence on LC, we demonstrate that there are still gaps and controversies in the diagnosis, pathophysiology, epidemiology, and detection of prognostic and predictive factors, as well as the role of the viral strain and vaccination.

摘要

新冠病毒仍然是一个主要的公共卫生关注点，主要是由于症状的持续存在或新症状的出现。迄今为止，已经描述了超过 200 种长新冠（LC）症状。本综述描述并绘制了其相关的临床特征、病理生理学、流行病学以及遗传和非遗传风险因素。鉴于目前关于 LC 的证据，我们表明，在诊断、病理生理学、流行病学以及预后和预测因素的检测，以及病毒株和疫苗的作用方面，仍然存在差距和争议。