Katiyar Deepti, Bansal Priya, Kumar Abhishek, Prakash Surya, Rao N G Raghavendra
Department of Pharmacognosy, KIET School of Pharmacy, KIET Group of Institutions, Ghaziabad, India.
Department of Pharmacology, KIET School of Pharmacy, KIET Group of Institutions, Ghaziabad, India.
J Food Biochem. 2022 Dec;46(12):e14452. doi: 10.1111/jfbc.14452. Epub 2022 Sep 27.
Sesquiterpenes are important in human health because they can treat viral infection, cardiovascular disease, and cancer. Sesquiterpenes have also been shown to increase the sensitivity of tumor cells to conventional pharmacological therapies, in addition to their antiviral effects. The present review article was drafted with an intention to gather information regarding sesquiterpenes and its medicinal importance. The role of sesquiterpenes in the endogenous production of sesquiterpenes by plants and fungi, as well as the mechanisms by which they are effective against viral infection, are discussed in this review. Different online libraries such as PUBMED, Sciencedirect, MEDLINE were assessed to gather information, additionally, books, magzagines, journals, and scientific newspapaers were also studied to make this article more informative. This review examines novel synthesis mechanisms, their cyclization, purification techniques, and the diverse ecological roles sesquiterpenes play in the plant producer, which varies according to the plant and the chemical under consideration. In this article, we have discussed the consequences of sesquiterpenes and their properties for future crop productivity. We have addressed the many forms of sesquiterpenes that have been shown to have antiviral activity in various diseases. The consequences of sesquiterpenes and their properties are very useful for future crop productivity. We have addressed the many forms of sesquiterpenes that have been shown to have antiviral activity in the treatment of various diseases. PRACTICAL APPLICATIONS: Novel synthesis mechanisms, their cyclization, purification techniques, and the diverse ecological roles of sesquiterpenes will be very helfpul in drug development process. Sesquiterpene lactones are shown in this review to have qualities that warrant further scientific investigation in order to stimulate preclinical and clinical trials leading to the creation of novel medications. For antiviral drug development, the sesquiterpenes are a good prospective lead molecule because they can suppress viral replication by disrupting vRNA production and viral protein production.
倍半萜类化合物对人体健康很重要，因为它们可以治疗病毒感染、心血管疾病和癌症。除了具有抗病毒作用外，倍半萜类化合物还被证明能提高肿瘤细胞对传统药物疗法的敏感性。撰写本综述文章的目的是收集有关倍半萜类化合物及其医学重要性的信息。本文讨论了倍半萜类化合物在植物和真菌内源性产生倍半萜类化合物中的作用，以及它们对抗病毒感染的作用机制。为了收集信息，评估了不同的在线数据库，如PUBMED、Sciencedirect、MEDLINE，此外，还研究了书籍、杂志、期刊和科学报纸，以使本文内容更丰富。本综述研究了新型合成机制、它们的环化、纯化技术，以及倍半萜类化合物在植物生产者中所起的不同生态作用，这些作用因植物和所考虑的化学物质而异。在本文中，我们讨论了倍半萜类化合物及其特性对未来作物生产力的影响。我们阐述了多种已被证明在各种疾病中具有抗病毒活性的倍半萜类化合物形式。倍半萜类化合物及其特性对未来作物生产力非常有用。我们阐述了多种已被证明在治疗各种疾病中具有抗病毒活性的倍半萜类化合物形式。实际应用：新型合成机制、它们的环化、纯化技术以及倍半萜类化合物的不同生态作用在药物开发过程中将非常有帮助。本综述表明，倍半萜内酯具有值得进一步科学研究的特性，以推动临床前和临床试验，从而开发新药物。对于抗病毒药物开发，倍半萜类化合物是一个很好的潜在先导分子，因为它们可以通过破坏病毒RNA的产生和病毒蛋白的产生来抑制病毒复制。
