Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang, Korea.
Miryang Agar-Agar CO. LTD., Miryang, Korea.
Biosci Biotechnol Biochem. 2022 Nov 23;86(12):1648-1657. doi: 10.1093/bbb/zbac159.
To investigate the effects of agar oligosaccharides (AO) on lipid metabolism, changes in obesity phenotypes and related molecular factors were evaluated in C57BL/6N mice fed a high-fat diet (HFD). When HFD-induced obese mice were fed AO, they lost weight. Also, fat accumulation in abdominal and liver tissues was lower in the AO groups than in the Vehicle group. Lipid droplet sizes in tissue sections were reduced by AO, and these observations were mirrored by serum lipid contents. To evaluate the effects of AO on lipid metabolism, lipogenesis and lipolysis-related factors were analyzed. The mRNA expressions of genes involved in lipogenesis, such as adipocyte-protein 2 (aP2) and fatty acid synthase (FAS), were reduced by AO administration, and the expressions of lipolysis-associated proteins, including perilipin, hormone-sensitive lipase (HSL), and fat triglyceride lipase (ATGL), were increased. Taken together, our results suggest that AO should be considered a valuable natural agent that inhibits obesity.
为了研究琼胶寡糖（AO）对脂代谢的影响，我们评估了高脂肪饮食（HFD）喂养的 C57BL/6N 小鼠肥胖表型的变化和相关分子因素。当 HFD 诱导肥胖小鼠喂食 AO 时，它们的体重减轻了。此外，AO 组的腹部和肝脏组织中的脂肪积累低于 Vehicle 组。组织切片中的脂滴大小被 AO 减小，血清脂质含量也反映了这一点。为了评估 AO 对脂代谢的影响，我们分析了与脂肪生成和脂肪分解相关的因素。AO 给药后，参与脂肪生成的基因如脂肪细胞蛋白 2（aP2）和脂肪酸合酶（FAS）的 mRNA 表达减少，而与脂肪分解相关的蛋白如围脂素、激素敏感脂肪酶（HSL）和脂肪甘油三酯脂肪酶（ATGL）的表达增加。综上所述，我们的结果表明，AO 可以被认为是一种有价值的天然抑制剂，可抑制肥胖。
