Kubota T, Kawano H, Yamashima T, Ikeda K, Hayashi M, Yamamoto S
Spine (Phila Pa 1976). 1987 May;12(4):317-23. doi: 10.1097/00007632-198705000-00002.
The ultrastructure of the formation of calcified nodules in three cases of symptomatic calcification of the cervical ligamentum flavum were studied. In some areas of the ligament, extracellular plasma membrane-invested matrix vesicles and thick wall-bound matrix giant bodies with or without mineralized deposits were present. These calcified vesicles and bodies were also encountered in the wide mineralized areas among the collagen and elastic fibers in the ligament. The mineralization process of the calcified nodules in the ligamentum flavum implies that matrix vesicles and matrix giant bodies acquire mineralized precipitates; then some gather in clusters. Calcified deposits may spread to collagen and elastic fibers contiguous with the calcified vesicles and bodies, and some eventually coalesce to make a calcified nodule.
对3例有症状的颈椎黄韧带钙化病例中钙化结节形成的超微结构进行了研究。在韧带的某些区域，存在细胞外被质膜包裹的基质小泡以及有或没有矿化沉积物的厚壁包绕的基质巨体。在韧带中胶原纤维和弹性纤维之间的广泛矿化区域也发现了这些钙化小泡和巨体。黄韧带中钙化结节的矿化过程表明，基质小泡和基质巨体获得矿化沉淀物；然后一些聚集在一起。钙化沉积物可能扩散到与钙化小泡和巨体相邻的胶原纤维和弹性纤维，一些最终融合形成钙化结节。
