Department of Ultrasound, Shenzhen Children's Hospital, Shenzhen, China.
Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China.
J Int Med Res. 2022 Sep;50(9):3000605221126378. doi: 10.1177/03000605221126378.
To explore the value of ultrasonography in the diagnosis and treatment of Langerhans cell histiocytosis (LCH) in children.
The clinical and imaging features of 55 children with pathologically confirmed LCH were retrospectively analyzed.
Thirteen patients had bone LCH and 42 had multisystem LCH. Among the 13 cases of bone LCH, 8 cases involving the skull and 2 involving the scapula were characterized by osteolytic bone destruction, 1 case involving the clavicle and 1 involving the iliac bone showed multiple irregular bone destruction, and 1 case involving the tibia showed local hypoechoic cortical bone. Soft tissue echo filling was present in the local areas of bone destruction. Among the 42 cases of multisystem LCH, 33 involved the bone, 35 showed an enlarged liver, 15 involved the spleen, 2 involved the pancreas, 3 involved the lung, 3 involved the thymus, and 21 affected the lymph nodes in different regions.
Ultrasonography of the flat bones in children with LCH mainly showed punched-out osteolytic bone destruction. Long bone lesions were characterized by fan shell changes in the endosteum of long bones, and some also showed bone destruction. Multisystem LCH can affect almost any organ. Ultrasonography is important for early diagnosis.
探讨超声在儿童朗格汉斯细胞组织细胞增生症（LCH）诊断和治疗中的价值。
回顾性分析 55 例经病理证实的 LCH 患儿的临床和影像学特征。
13 例为骨 LCH，42 例为多系统 LCH。在 13 例骨 LCH 中，8 例累及颅骨，2 例累及肩胛骨，表现为溶骨性骨破坏；1 例累及锁骨，1 例累及髂骨，表现为多发不规则骨破坏；1 例累及胫骨，表现为局部皮质骨低回声。骨破坏局部有软组织回声填充。在 42 例多系统 LCH 中，33 例累及骨骼，35 例肝脏肿大，15 例脾脏受累，2 例胰腺受累，3 例肺部受累，3 例胸腺受累，21 例不同部位淋巴结受累。
儿童 LCH 的扁平骨超声主要表现为凿孔样溶骨性骨破坏。长骨病变特征为长骨干骺端扇形壳样改变，部分也有骨破坏。多系统 LCH 几乎可累及任何器官。超声检查对早期诊断具有重要价值。
