National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China.
Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Cell Biol Toxicol. 2023 Oct;39(5):2431-2435. doi: 10.1007/s10565-022-09771-9. Epub 2022 Sep 28.
Horseshoe bats (Rhinolophus sinicus) might help maintain coronaviruses severely affecting human health, such as severe acute respiratory syndrome coronavirus (SARS-CoV). Bats may be more tolerant of viral infection than other mammals due to their unique immune system, but the exact mechanism remains to be fully explored. During the coronavirus disease 2019 (COVID-19) pandemic, multiple animal species were diseased by coronavirus infection, especially in the respiratory system. Herein, a comparative analysis with single nucleus transcriptomic data of the lungs across four species, including horseshoe bat, cat, tiger, and pangolin, were conducted. The distribution of entry factors for twenty-eight respiratory viruses was characterized for the four species. Our findings might increase our understanding of the immune background of horseshoe bats.
马蹄蝠（Rhinolophus sinicus）可能有助于维持严重影响人类健康的冠状病毒，例如严重急性呼吸综合征冠状病毒（SARS-CoV）。由于其独特的免疫系统，蝙蝠可能比其他哺乳动物更能耐受病毒感染，但确切的机制仍有待充分探索。在 2019 年冠状病毒病（COVID-19）大流行期间，多种动物物种因冠状病毒感染而患病，尤其是在呼吸系统。在此，对包括马蹄蝠、猫、老虎和穿山甲在内的四个物种的肺部单细胞转录组数据进行了比较分析。对这四个物种的二十八种呼吸道病毒的进入因子的分布进行了描述。我们的研究结果可能会增加我们对马蹄蝠免疫背景的理解。
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