部分诱导的Mucts62原噬菌体对大肠杆菌染色体缺失的刺激作用。
Stimulation of deletions in the Escherichia coli chromosome by partially induced Mucts62 prophages.
作者信息
Faelen M, Toussaint A
出版信息
J Bacteriol. 1978 Nov;136(2):477-83. doi: 10.1128/jb.136.2.477-483.1978.
Abstract
Deletion of bacterial DNA fragments is stimulated in induced Mucts62 lysogens. The host genes located proximally to the prophage are more frequently lost than those which are unlinked to the Mu genome. Genes located on either side of a Mu genome are deleted in the same manner. Like the other Mu-induced rearrangements, this process is recA independent and requires the participation of Mu DNA, as indicated by the fact that a phage genome always replaces the deleted genes. Data are presented which strongly suggest that both ends of the Mu genome are involved in deletion formation.
摘要
在诱导的Mucts62溶源菌中，细菌DNA片段的缺失受到刺激。位于原噬菌体近端的宿主基因比那些与Mu基因组不连锁的基因更频繁地丢失。位于Mu基因组两侧的基因以相同的方式被删除。与其他Mu诱导的重排一样，这个过程不依赖recA，并且需要Mu DNA的参与，这一事实表明噬菌体基因组总是取代被删除的基因。所呈现的数据强烈表明Mu基因组的两端都参与了缺失的形成。
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