脑脊液的循环和扩散使颅内腔室的清除迅速。

CSF circulation and dispersion yield rapid clearance from intracranial compartments.

作者信息

Hornkjøl Martin, Valnes Lars Magnus, Ringstad Geir, Rognes Marie E, Eide Per-Kristian, Mardal Kent-André, Vinje Vegard

机构信息

Department of Mathematics, University of Oslo, Blindern, Norway.

Department of Neurosurgery, Oslo University Hospital-Rikshospitalet, Oslo, Norway.

出版信息

Front Bioeng Biotechnol. 2022 Sep 12;10:932469. doi: 10.3389/fbioe.2022.932469. eCollection 2022.

Abstract

In this paper, we used a computational model to estimate the clearance of a tracer driven by the circulation of cerebrospinal fluid (CSF) produced in the choroid plexus (CP) located within the lateral ventricles. CSF was assumed to exit the subarachnoid space (SAS) via different outflow routes such as the parasagittal dura, cribriform plate, and/or meningeal lymphatics. We also modelled a reverse case where fluid was produced within the spinal canal and absorbed in the choroid plexus in line with observations on certain iNPH patients. No directional interstitial fluid flow was assumed within the brain parenchyma. Tracers were injected into the foramen magnum. The models demonstrate that convection in the subarachnoid space yields rapid clearance from both the SAS and the brain interstitial fluid and can speed up intracranial clearance from years, as would be the case for purely diffusive transport, to days.

摘要

在本文中,我们使用了一个计算模型来估计由位于侧脑室内的脉络丛(CP)产生的脑脊液(CSF)循环驱动的示踪剂清除情况。脑脊液被假定通过不同的流出途径离开蛛网膜下腔(SAS),如矢状窦旁硬脑膜、筛板和/或脑膜淋巴管。我们还模拟了一种相反的情况,即根据对某些正常压力脑积水(iNPH)患者的观察,液体在椎管内产生并在脉络丛中被吸收。在脑实质内未假定有方向性的间质液流动。示踪剂被注入枕骨大孔。模型表明,蛛网膜下腔内的对流可使示踪剂从蛛网膜下腔和脑间质液中快速清除,并且可以将颅内清除时间从数年(如纯扩散运输的情况)加快到数天。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b45/9510842/9854abc12ad0/fbioe-10-932469-g001.jpg

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