探究自闭症谱系特质对面孔加工机制在发展性面孔失认症中的影响。
Investigating the Influence of Autism Spectrum Traits on Face Processing Mechanisms in Developmental Prosopagnosia.
机构信息
Boston Attention and Learning Laboratory, VA Boston Healthcare System, 150 S. Huntington Ave., 182JP, Boston, MA, 02130, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
出版信息
J Autism Dev Disord. 2023 Dec;53(12):4787-4808. doi: 10.1007/s10803-022-05705-w. Epub 2022 Sep 29.
Autism traits are common exclusionary criteria in developmental prosopagnosia (DP) studies. We investigated whether autism traits produce qualitatively different face processing in 43 DPs with high vs. low autism quotient (AQ) scores. Compared to controls (n = 27), face memory and perception were similarly deficient in the high- and low-AQ DPs, with the high-AQ DP group additionally showing deficient face emotion recognition. Task-based fMRI revealed reduced occipito-temporal face selectivity in both groups, with high-AQ DPs additionally demonstrating decreased posterior superior temporal sulcus selectivity. Resting-state fMRI showed similar reduced face-selective network connectivity in both DP groups compared with controls. Together, this demonstrates that high- and low-AQ DP groups have very similar face processing deficits, with additional facial emotion deficits in high-AQ DPs.
自闭症特征是发展性面孔失认症（DP）研究中常见的排除标准。我们研究了自闭症特征是否会导致高自闭症商数（AQ）和低自闭症商数（AQ）的 43 名 DP 患者产生不同性质的面孔处理。与对照组（n=27）相比，高 AQ 和低 AQ DP 患者的面孔记忆和感知同样存在缺陷，而高 AQ DP 组还表现出面孔情绪识别缺陷。基于任务的 fMRI 显示，两组的枕颞部面孔选择性均降低，高 AQ DP 患者的后上颞叶选择性进一步降低。静息状态 fMRI 显示，与对照组相比，两组 DP 患者的面孔选择性网络连接相似减少。总的来说，这表明高 AQ 和低 AQ DP 患者的面孔处理缺陷非常相似，高 AQ DP 患者还存在额外的面部情绪缺陷。
Zotero 插件