Center for Pain Research and Behavioral Health.
Exp Clin Psychopharmacol. 2023 Apr;31(2):433-442. doi: 10.1037/pha0000602. Epub 2022 Sep 29.
Research suggests situational pain may motivate alcohol consumption, suggesting that pain may be an antecedent for problematic drinking behavior. In this pilot project, we assessed the effect of a painful thermal stimulus on drinking topography in a virtual reality bar environment using real alcohol-containing beverages. We also examined psychosocial factors that may account for individual differences in pain as an antecedent for alcohol use. Participants ( = 20, = 25.65 years, 55% female, 15% Hispanic/Latino/a/x) completed a psychosocial screening battery before completing two counterbalanced alcohol self-administration sessions. In each, participants experienced either painful heat (44 °C) or nonnoxious warmth (38 °C). Sip interval (s) and sip volume (g) were measured. Effects of pain on drinking topography were assessed using multilevel models. Multilevel models assessed associations of pain-related changes in topography with hypothesized vulnerability factors. Analyses indicated a significant interaction of pain condition and sex on sip interval ( = -.16.96, = .015, 95% CI [-30.75, -2.97]), such that painful heat significantly decreased sip interval in men ( = 16.38) but not women ( = -.45). No effect of pain on sip volume was detected ( > .49). Exploratory analyses indicated significant interactions such that the effect of the painful heat condition was stronger in individuals with higher levels of greater negative urgency but the opposite effect for pain catastrophizing. Results suggest acute pain has sex-contingent effects on drinking topography, such that men drank more rapidly while experiencing painful heat. Furthermore, analyses indicated that individuals with greater negative urgency, regardless of sex, may be at elevated risk for hazardous alcohol use when experiencing pain. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
研究表明情境性疼痛可能会促使人们饮酒,这表明疼痛可能是导致问题性饮酒行为的一个前置因素。在这个试点项目中,我们在虚拟现实酒吧环境中使用含酒精的真实饮料,评估了疼痛性热刺激对饮酒行为的影响。我们还研究了可能导致疼痛作为饮酒前置因素的个体差异的心理社会因素。参与者(n = 20,平均年龄 25.65 岁,女性占 55%,西班牙裔/拉丁裔占 15%)在完成两项平衡的酒精自我给药任务之前,完成了一份心理社会筛查量表。在每一项任务中,参与者都经历了疼痛性热刺激(44°C)或非伤害性温暖刺激(38°C)。测量了啜饮间隔(s)和啜饮量(g)。使用多层模型评估疼痛对饮酒行为的影响。多层模型评估了与假设易感性因素相关的疼痛相关变化与饮酒行为的关系。分析表明,疼痛条件和性别对啜饮间隔的交互作用显著(β=-.16,95%CI [-30.75,-2.97],p=.015),即疼痛性热刺激显著降低了男性的啜饮间隔(β=16.38),但对女性没有影响(β=-.45)。疼痛对啜饮量没有影响(p>.49)。探索性分析表明,存在显著的交互作用,即疼痛性热刺激条件的影响在更高水平的更强的负性冲动个体中更强,但对疼痛灾难化的影响则相反。结果表明,急性疼痛对男性的饮酒行为有性别依赖的影响,即男性在经历疼痛性热刺激时会更快地饮酒。此外,分析表明,无论性别如何,具有更大负性冲动的个体在经历疼痛时可能面临更高的危险饮酒风险。(PsycInfo 数据库记录(c)2023 APA,保留所有权利)。