Lowenthal D T, Onesti G, Mutterperl R, Affrime M, Martinez E W, Kim K E, Busby P, Shirk J, Swartz C
J Clin Pharmacol. 1978 Oct;18(10):500-8. doi: 10.1002/j.1552-4604.1978.tb01578.x.
Minoxidil was used to treat 26 patients (17 to 67 years old) with severe hypertension and varying degrees of renal function. Our object was to assess long-term clinical efficacy, kinetics (acute and chronic), and bioavailability of minoxidil in chronic renal insufficiency. Minoxidil, 27 to 30 mg per day, decreased systolic and diastolic blood pressure during the first three months of therapy. Between the third and 24th months (30 months in one patient) there was no further change. Propranolol or clonidine was needed to control heart rate, and furosemide or dialysis was needed to control edema induced by minoxidil. Renal function improved in some of the mildy azotemic patients. Minoxidil kinetics after the customary dose did not differ whether the drug was taken as tablet or solution. Kinetic parameters during chronic administration of minoxidil did not differ from those after acute administration. The kinetics in chronic renal insufficiency do not differ from these in subjects with normal renal function.
米诺地尔用于治疗26例年龄在17至67岁之间、患有重度高血压且肾功能程度各异的患者。我们的目的是评估米诺地尔在慢性肾功能不全患者中的长期临床疗效、动力学（急性和慢性）及生物利用度。每日服用27至30毫克米诺地尔，在治疗的前三个月收缩压和舒张压下降。在第三个月至第24个月期间（1例患者为30个月）血压无进一步变化。需要使用普萘洛尔或可乐定来控制心率，使用呋塞米或透析来控制米诺地尔引起的水肿。部分轻度氮质血症患者的肾功能有所改善。常规剂量的米诺地尔无论是以片剂还是溶液形式服用，其动力学无差异。米诺地尔慢性给药期间的动力学参数与急性给药后无差异。慢性肾功能不全患者的动力学与肾功能正常者无异。
