表皮干细胞在皮肤创伤修复中的作用及机制研究进展
[Research advances on the role and mechanism of epidermal stem cells in skin wound repair].
作者信息
Shi Z Y, Zhang B H, Sun J C, Liu X Z, Shen Z A
机构信息
Department of Burns and Plastic Surgery, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China.
出版信息
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Sep 20;38(9):854-858. doi: 10.3760/cma.j.cn501120-20211109-00382.
Epidermal stem cells play an pivotal role in skin self-renewal, wound repair, and re-epithelialization process. The emergence of new technologies and concepts such as single-cell sequencing and gene knockout further revealed a new mechanism of epidermal stem cells in epidermal self-renewal and wound repair, providing new ideas for wound repair. In this review, the mechanisms of proliferation, differentiation, and migration of epidermal stem cells are discussed. Combined with the analysis of researches on stem cell heterogeneity and cell plasticity, the physiological function of epidermal stem cells can be further understood. The application advances of epidermal stem cells in wound repair is also summarized, which would provide some advice for workers engaged in clinical and basic research on wound repair.
表皮干细胞在皮肤自我更新、伤口修复和再上皮化过程中发挥着关键作用。单细胞测序和基因敲除等新技术和概念的出现，进一步揭示了表皮干细胞在表皮自我更新和伤口修复中的新机制，为伤口修复提供了新思路。在这篇综述中，讨论了表皮干细胞的增殖、分化和迁移机制。结合对干细胞异质性和细胞可塑性研究的分析，可进一步了解表皮干细胞的生理功能。还总结了表皮干细胞在伤口修复中的应用进展，这将为从事伤口修复临床和基础研究的工作者提供一些建议。
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