Centre for Tissue Engineering and Regenerative Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur 56000, Malaysia.
Int J Mol Sci. 2021 Jun 17;22(12):6486. doi: 10.3390/ijms22126486.
Skin injury is quite common, and the wound healing is a complex process involving many types of cells, the extracellular matrix, and soluble mediators. Cell differentiation, migration, and proliferation are essential in restoring the integrity of the injured tissue. Despite the advances in science and technology, we have yet to find the ideal dressing that can support the healing of cutaneous wounds effectively, particularly for difficult-to-heal chronic wounds such as diabetic foot ulcers, bed sores, and venous ulcers. Hence, there is a need to identify and incorporate new ideas and methods to design a more effective dressing that not only can expedite wound healing but also can reduce scarring. Calcium has been identified to influence the wound healing process. This review explores the functions and roles of calcium in skin regeneration and reconstruction during would healing. Furthermore, this review also investigates the possibility of incorporating calcium into scaffolds and examines how it modulates cutaneous wound healing. In summary, the preliminary findings are promising. However, some challenges remain to be addressed before calcium can be used for cutaneous wound healing in clinical settings.
皮肤损伤很常见，而伤口愈合是一个涉及多种细胞、细胞外基质和可溶性介质的复杂过程。细胞分化、迁移和增殖对于恢复受损组织的完整性至关重要。尽管科学技术取得了进步，但我们尚未找到理想的敷料，能够有效地支持皮肤伤口的愈合，特别是对于难以愈合的慢性伤口，如糖尿病足溃疡、褥疮和静脉溃疡。因此，需要确定并采用新的理念和方法来设计更有效的敷料，不仅可以加速伤口愈合，还可以减少疤痕形成。钙已被确定会影响伤口愈合过程。本综述探讨了钙在伤口愈合过程中对皮肤再生和重建的功能和作用。此外，本综述还研究了将钙纳入支架的可能性，并探讨了其如何调节皮肤伤口愈合。总的来说，初步研究结果很有前景。然而，在将钙用于临床皮肤伤口愈合之前，仍需要解决一些挑战。
