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通过与佐剂的超分子功能化增强细菌的免疫原性。

Chemically Enhanced Immunogenicity of Bacteria by Supramolecular Functionalization with an Adjuvant.

机构信息

Interventional Molecular Imaging (IMI) Laboratory, Departments of Radiology & Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333 RC, Leiden (The, Netherlands.

Interventional Molecular Imaging (IMI) Laboratory, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 RC, Leiden (The, Netherlands.

出版信息

Chembiochem. 2022 Dec 5;23(23):e202200434. doi: 10.1002/cbic.202200434. Epub 2022 Nov 4.

DOI:10.1002/cbic.202200434
PMID:36177993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10098600/
Abstract

Many pathogens blunt immune responses because they lack immunogenic structural features, which typically results in disease. Here, we show evidence suggesting that pathogen immunogenicity can be chemically enhanced. Using supramolecular host-guest chemistry, we complexed onto the surface of a poorly immunogenic bacterium (Staphylococcus aureus) a TLR7 agonist-based adjuvant. "Adjuvanted" bacteria were readily recognized by macrophages and induced a more pro-inflammatory immunophenotype. Future applications of this concept could yield treatment modalities that bolster the immune system's response to pathogenic microbes.

摘要

许多病原体削弱了免疫反应，因为它们缺乏免疫原性结构特征，这通常导致疾病。在这里，我们提供的证据表明病原体的免疫原性可以通过化学方法增强。我们利用超分子主体-客体化学，将 TLR7 激动剂佐剂复合到免疫原性差的细菌（金黄色葡萄球菌）表面上。“佐剂化”的细菌很容易被巨噬细胞识别，并诱导出更具炎症表型的免疫反应。这一概念的未来应用可能会产生治疗模式，增强免疫系统对致病微生物的反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e51/10098600/09a1c994935c/CBIC-23-0-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e51/10098600/e0d11c8362a9/CBIC-23-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e51/10098600/7644970231bf/CBIC-23-0-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e51/10098600/aea63f9e5120/CBIC-23-0-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e51/10098600/dc09e20416ea/CBIC-23-0-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e51/10098600/ae41ca7e76d2/CBIC-23-0-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e51/10098600/09a1c994935c/CBIC-23-0-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e51/10098600/e0d11c8362a9/CBIC-23-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e51/10098600/7644970231bf/CBIC-23-0-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e51/10098600/aea63f9e5120/CBIC-23-0-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e51/10098600/dc09e20416ea/CBIC-23-0-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e51/10098600/ae41ca7e76d2/CBIC-23-0-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e51/10098600/09a1c994935c/CBIC-23-0-g007.jpg

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