通过配体促进无张力酮的 C-C 键断裂构建 C(sp)-Si 键。
Construction of C(sp)-Si Bonds via Ligand-Promoted C-C Bonds Cleavage of Unstrained Ketones.
机构信息
CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.
出版信息
Org Lett. 2022 Oct 14;24(40):7344-7349. doi: 10.1021/acs.orglett.2c02841. Epub 2022 Sep 30.
Herein, we report an efficient palladium-catalyzed silylation of aryl and alkenyl ketones via C-C bond cleavage and C-Si bond formation. This protocol features high efficiency and broad substrate scope. Further applications in the late-stage diversification of biologically important molecules demonstrate the synthetic utility of this method.
在此，我们报告了一种通过 C-C 键断裂和 C-Si 键形成来实现芳基和烯基酮的高效钯催化硅烷化反应。该方案具有高效率和广泛的底物范围。在生物重要分子的后期多样化中的进一步应用证明了该方法的合成实用性。
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