Abd El Fattah Yasmine K, Abulsoud Ahmed I, AbdelHamid Sherihan G, Hamdy Nadia M
Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy (Boys' Branch), Al-Azhar University, Nasr City, Cairo, Egypt.
Int J Biol Macromol. 2022 Dec 1;222(Pt B):1676-1687. doi: 10.1016/j.ijbiomac.2022.09.209. Epub 2022 Sep 28.
Long non-coding RNAs (lncRNAs) were, once, viewed as "noise" for transcription. Recently, many lncRNAs are functionally linked to several human disorders, including cancer. Coiled-Coil Domain Containing 144 N-Terminal-Like antisense1 (CCDC144NL-AS1) is a newly discovered cytosolic lncRNA. Aberrant CCDC144NL-AS1 expression was discovered in hepatocellular carcinoma (HCC), ovarian cancer (OC), gastric cancer (GC), non-small cell lung cancer (NSCLC), and osteosarcoma. CCDC144NL-AS1 could be a promising prognostic biological marker and therapeutic target for cancer. In this review, we will collect and highlight the available information about CCDC144NL-AS1 role in various cancers. Moreover, we will discuss the diagnostic and prognostic utility of CCDC144NL-AS1 as a new molecular biomarker for several human malignancies, besides its potential therapeutic importance.
长链非编码RNA（lncRNAs）曾一度被视为转录过程中的“噪音”。近来，许多lncRNAs在功能上与包括癌症在内的多种人类疾病相关联。含卷曲螺旋结构域144 N端样反义RNA1（CCDC144NL-AS1）是一种新发现的胞质lncRNA。在肝细胞癌（HCC）、卵巢癌（OC）、胃癌（GC）、非小细胞肺癌（NSCLC）和骨肉瘤中均发现CCDC144NL-AS1表达异常。CCDC144NL-AS1有望成为一种有前景的癌症预后生物学标志物和治疗靶点。在本综述中，我们将收集并重点介绍有关CCDC144NL-AS1在各种癌症中作用的现有信息。此外，除了其潜在的治疗重要性外，我们还将讨论CCDC144NL-AS1作为几种人类恶性肿瘤新分子生物标志物的诊断和预后效用。
