Shi Liqin, Han Xueya, Liu Fang, Long Jinzhao, Jin Yuefei, Chen Shuaiyin, Duan Guangcai, Yang Haiyan
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Curr Issues Mol Biol. 2024 Jul 17;46(7):7558-7576. doi: 10.3390/cimb46070449.
The confrontation between humans and bacteria is ongoing, with strategies for combating bacterial infections continually evolving. With the advancement of RNA sequencing technology, non-coding RNAs (ncRNAs) associated with bacterial infections have garnered significant attention. Recently, long ncRNAs (lncRNAs) have been identified as regulators of sterile inflammatory responses and cellular defense against live bacterial pathogens. They are involved in regulating host antimicrobial immunity in both the nucleus and cytoplasm. Increasing evidence indicates that lncRNAs are critical for the intricate interactions between host and pathogen during bacterial infections. This paper emphatically elaborates on the potential applications of lncRNAs in clinical hallmarks, cellular damage, immunity, virulence, and drug resistance in bacterial infections in greater detail. Additionally, we discuss the challenges and limitations of studying lncRNAs in the context of bacterial infections and highlight clear directions for this promising field.
人类与细菌之间的对抗一直在持续，对抗细菌感染的策略也在不断演变。随着RNA测序技术的进步，与细菌感染相关的非编码RNA（ncRNAs）已引起了广泛关注。最近，长链非编码RNA（lncRNAs）已被确定为无菌性炎症反应和针对活细菌病原体的细胞防御的调节因子。它们参与在细胞核和细胞质中调节宿主的抗菌免疫。越来越多的证据表明，lncRNAs在细菌感染期间宿主与病原体之间的复杂相互作用中至关重要。本文更详细地着重阐述了lncRNAs在细菌感染的临床特征、细胞损伤、免疫、毒力和耐药性方面的潜在应用。此外，我们讨论了在细菌感染背景下研究lncRNAs的挑战和局限性，并突出了这个有前景领域的明确方向。
