运动学习重塑髓鞘景观。
Motor learning revamps the myelin landscape.
机构信息
Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
出版信息
Nat Neurosci. 2022 Oct;25(10):1251-1252. doi: 10.1038/s41593-022-01156-9.
Abstract
Learning requires new oligodendrogenesis, but how myelin patterns change during learning is unclear. Bacmeister et al. show that motor learning induces phase-specific changes in myelination on behaviorally activated axons that correlate with motor performance, suggesting myelin remodeling is involved in learning.
摘要
学习需要新的少突胶质细胞生成，但学习过程中髓鞘模式如何变化尚不清楚。Bacmeister 等人表明，运动学习会导致行为激活的轴突上的髓鞘形成出现特定相位的变化，与运动表现相关，这表明髓鞘重塑参与了学习。
相似文献
1
Motor learning revamps the myelin landscape.运动学习重塑髓鞘景观。
Nat Neurosci. 2022 Oct;25(10):1251-1252. doi: 10.1038/s41593-022-01156-9.
2
Regulation of lipid synthesis in myelin modulates neural activity and is required for motor learning.髓鞘中脂质合成的调节可调节神经活动，是运动学习所必需的。
Glia. 2023 Nov;71(11):2591-2608. doi: 10.1002/glia.24441. Epub 2023 Jul 20.
3
Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons.运动学习驱动学习激活轴突上间歇性髓鞘化的动态模式。
Nat Neurosci. 2022 Oct;25(10):1300-1313. doi: 10.1038/s41593-022-01169-4. Epub 2022 Sep 30.
4
Motor skill learning requires active central myelination.运动技能学习需要活跃的中枢髓鞘形成。
Science. 2014 Oct 17;346(6207):318-22. doi: 10.1126/science.1254960.
5
Gene profiling in the dynamic regulation of the lifespan of the myelin sheath structure in the optic nerve of rats.大鼠视神经髓鞘结构寿命动态调节中的基因谱分析
Mol Med Rep. 2014 Jul;10(1):217-22. doi: 10.3892/mmr.2014.2227. Epub 2014 May 9.
6
Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity.运动学习需要髓鞘形成来减少神经活动中的异步性和自发性。
Glia. 2020 Jan;68(1):193-210. doi: 10.1002/glia.23713. Epub 2019 Aug 29.
7
Myelin as longitudinal conductor: a multi-layered model of the myelinated human motor nerve fibre.髓鞘作为纵向导体：有髓鞘的人类运动神经纤维的多层模型。
Biol Cybern. 2001 Apr;84(4):301-8. doi: 10.1007/s004220000213.
8
Effects of estrogen replacement therapy on the myelin sheath ultrastructure of myelinated fibers in the white matter of middle-aged ovariectomized rats.雌激素替代疗法对中年去卵巢大鼠白质有髓纤维髓鞘超微结构的影响。
J Comp Neurol. 2018 Apr 1;526(5):790-802. doi: 10.1002/cne.24366. Epub 2017 Dec 17.
9
Myelin plasticity modulates neural circuitry required for learning and behavior.髓鞘的可塑性调节学习和行为所需的神经回路。
Neurosci Res. 2021 Jun;167:11-16. doi: 10.1016/j.neures.2020.12.005. Epub 2021 Jan 5.
10
Biomechanically-Adapted Immunohydrogels Reconstructing Myelin Sheath for Peripheral Nerve Regeneration.生物力学适配免疫水凝胶构建用于周围神经再生的髓鞘。
Adv Healthc Mater. 2022 Oct;11(20):e2201596. doi: 10.1002/adhm.202201596. Epub 2022 Sep 9.
引用本文的文献
1
Myelin sheaths can act as compact temporary oxygen storage units as modeled by an electrical RC circuit model.髓鞘可作为紧凑的临时储氧单元，这是由一个电气RC电路模型模拟得出的。
Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2422437122. doi: 10.1073/pnas.2422437122. Epub 2025 May 16.
2
Neural reshaping: the plasticity of human brain and artificial intelligence in the learning process.神经重塑：人类大脑与人工智能在学习过程中的可塑性
Am J Neurodegener Dis. 2024 Dec 25;13(5):34-48. doi: 10.62347/NHKD7661. eCollection 2024.
3
DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact.Myrf 敲除小鼠海马中的 DUSP15 表达减少，但注意力和物体识别记忆保持完整。
PLoS One. 2023 Feb 2;18(2):e0281264. doi: 10.1371/journal.pone.0281264. eCollection 2023.
4
Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration.染色质重塑的小分子调节剂：从神经发育到神经退行性变
Cell Biosci. 2023 Jan 16;13(1):10. doi: 10.1186/s13578-023-00953-4.
本文引用的文献
1
Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons.运动学习驱动学习激活轴突上间歇性髓鞘化的动态模式。
Nat Neurosci. 2022 Oct;25(10):1300-1313. doi: 10.1038/s41593-022-01169-4. Epub 2022 Sep 30.
2
Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain.周质和节段可塑性调节成年小鼠大脑中的动作电位传导。
Cell Rep. 2021 Jan 19;34(3):108641. doi: 10.1016/j.celrep.2020.108641.
3
Neuron class-specific responses govern adaptive myelin remodeling in the neocortex.神经元类特异性反应控制大脑新皮层中的适应性髓鞘重塑。
Science. 2020 Dec 18;370(6523). doi: 10.1126/science.abd2109.
4
Mechanisms of node of Ranvier assembly.郎飞结组装的机制。
Nat Rev Neurosci. 2021 Jan;22(1):7-20. doi: 10.1038/s41583-020-00406-8. Epub 2020 Nov 25.
5
Myelin plasticity: sculpting circuits in learning and memory.髓鞘可塑性：学习和记忆中的电路塑造。
Nat Rev Neurosci. 2020 Dec;21(12):682-694. doi: 10.1038/s41583-020-00379-8. Epub 2020 Oct 12.
6
Motor learning promotes remyelination via new and surviving oligodendrocytes.运动学习通过新的和存活的少突胶质细胞促进髓鞘再生。
Nat Neurosci. 2020 Jul;23(7):819-831. doi: 10.1038/s41593-020-0637-3. Epub 2020 May 18.
7
Cortical Synaptic AMPA Receptor Plasticity during Motor Learning.运动学习过程中皮质突触 AMPA 受体的可塑性。
Neuron. 2020 Mar 4;105(5):895-908.e5. doi: 10.1016/j.neuron.2019.12.005. Epub 2019 Dec 31.
8
Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex.个体少突胶质细胞在新皮层中表现出对抑制性轴突的偏向性。
Cell Rep. 2019 Jun 4;27(10):2799-2808.e3. doi: 10.1016/j.celrep.2019.05.018.
9
Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner.药物遗传学刺激神经元活动以轴突特异性方式增加髓鞘形成。
Nat Commun. 2018 Jan 22;9(1):306. doi: 10.1038/s41467-017-02719-2.
10
Motor skill learning requires active central myelination.运动技能学习需要活跃的中枢髓鞘形成。
Science. 2014 Oct 17;346(6207):318-22. doi: 10.1126/science.1254960.
Zotero 插件