Ghafouri-Fard Soudeh, Bahroudi Zahra, Shoorei Hamed, Hussen Bashdar Mahmud, Talebi Seyedeh Fahimeh, Baig Sadia Ghousia, Taheri Mohammad, Ayatollahi Seyed Abdulmajid
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Cancer Cell Int. 2022 Sep 30;22(1):298. doi: 10.1186/s12935-022-02719-3.
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural phenol that is present in the skin of the grape, blueberry, raspberry, mulberry, and peanut. This substance is synthesized in these plants following injury or exposure to pathogens. Resveratrol is used as a dietary supplement for a long time and its effects have been assessed in animal models of human disorders. It has potential beneficial effects in diverse pathological conditions such as diabetes mellitus, obesity, hypertension, neoplastic conditions, Alzheimer's disease, and cardiovascular disorders. Notably, resveratrol has been found to affect the expression of several genes including cytokine coding genes, caspases, matrix metalloproteinases, adhesion molecules, and growth factors. Moreover, it can modulate the activity of several signaling pathways such as PI3K/AKT, Wnt, NF-κB, and Notch pathways. In the current review, we summarize the results of studies that reported modulatory effects of resveratrol on the expression of genes and the activity of signaling pathways. We explain these results in two distinct sections of non-neoplastic and neoplastic conditions.
白藜芦醇（3,5,4'-三羟基反式芪）是一种天然酚类物质，存在于葡萄、蓝莓、树莓、桑椹和花生的表皮中。这种物质在这些植物受到损伤或接触病原体后会合成。长期以来，白藜芦醇一直被用作膳食补充剂，其效果已在人类疾病的动物模型中得到评估。它在多种病理状况下具有潜在的有益作用，如糖尿病、肥胖症、高血压、肿瘤疾病、阿尔茨海默病和心血管疾病。值得注意的是，已发现白藜芦醇会影响多个基因的表达，包括细胞因子编码基因、半胱天冬酶、基质金属蛋白酶、黏附分子和生长因子。此外，它可以调节多种信号通路的活性，如PI3K/AKT、Wnt、NF-κB和Notch通路。在本综述中，我们总结了报道白藜芦醇对基因表达和信号通路活性具有调节作用的研究结果。我们在非肿瘤和肿瘤状况这两个不同部分对这些结果进行解释。
