Department of Public Health & Maternal and Child Health, Faculty of Medicine, Universidad Complutense de Madrid, IdISSC, 28040, Madrid, Spain.
Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Rey Juan Carlos University, Alcorcón, Madrid, Spain.
Cardiovasc Diabetol. 2022 Sep 30;21(1):198. doi: 10.1186/s12933-022-01633-2.
We performed a study to assess sex-differences in incidence (2016-2020), clinical characteristics, use of therapeutic procedures, and in-hospital outcomes in patients with infective endocarditis (IE) according to T2DM status.
Ours was a retrospective cohort study using data from the Spanish National Hospital Discharge Database. We estimated the incidence of hospitalizations for IE in men and women aged ≥ 40 years with and without T2DM. Propensity score matching (PSM) and multivariable logistic regression were used to compare subgroups according to sex and the presence of T2DM.
From 2016 to 2020, IE was coded in 9,958 patients (66.79% men). T2DM was diagnosed in 2,668 (26.79%). The incidence of IE increased significantly from 15.29 cases per 100,000 persons with T2DM in 2016 to 17.69 in 2020 (p < 0.001). However, this increment was significant only among men with T2DM (19.47 cases per 100,000 in 2016 vs. 22.84 in 2020; p = 0.003). The age-adjusted incidence of IE was significantly higher in people with T2DM (both sexes) than in those without T2DM (IRR, 2.86; 95% CI, 2.74-2.99). The incidence of IE was higher in men with T2DM than in women with T2DM (adjusted IRR, 1.85; 95% CI, 1.54-3.31). After PSM, in-hospital mortality (IHM) was higher among T2DM women than matched T2DM men (22.65% vs. 18.0%; p = 0.018). The presence of T2DM was not associated with IHM in men or women.
T2DM is associated with a higher incidence of hospitalization for IE. Findings for T2DM patients who had experienced IE differed by sex, with higher incidence rates and lower IHM in men than in women. T2DM was not associated to IHM in IE in men or in women.
我们进行了一项研究，以评估根据 2 型糖尿病（T2DM）状态，在感染性心内膜炎（IE）患者中，发病率（2016-2020 年）、临床特征、治疗程序的使用和住院结局方面的性别差异。
这是一项使用西班牙国家住院数据库数据的回顾性队列研究。我们估计了年龄≥40 岁的男性和女性中 T2DM 患者和非 T2DM 患者的 IE 住院发病率。采用倾向评分匹配（PSM）和多变量逻辑回归比较了按性别和 T2DM 分组的亚组。
2016 年至 2020 年期间，9958 例患者（66.79%为男性）被诊断为 IE。2668 例（26.79%）诊断为 T2DM。IE 的发病率从 2016 年每 100,000 人 15.29 例显著增加到 2020 年的每 100,000 人 17.69 例（p<0.001）。然而，这种增加仅在男性 T2DM 患者中显著（2016 年每 100,000 人 19.47 例 vs. 2020 年每 100,000 人 22.84 例；p=0.003）。T2DM 患者（无论性别）的 IE 发病率均高于非 T2DM 患者（调整发病率比，2.86；95%可信区间，2.74-2.99）。T2DM 男性 IE 发病率高于 T2DM 女性（调整发病率比，1.85；95%可信区间，1.54-3.31）。PSM 后，T2DM 女性的院内死亡率（IHM）高于匹配的 T2DM 男性（22.65%比 18.0%；p=0.018）。T2DM 与男性或女性的 IHM 无关。
T2DM 与 IE 住院发病率增加有关。T2DM 患者中 IE 的发生率因性别而异，男性的发病率更高，而女性的 IHM 更低。T2DM 与男性或女性 IE 患者的 IHM 无关。
