School of Psychological Sciences and Health, University of Strathclyde, Graham Hills Building, 40 George Street, Glasgow, G1 1QE, UK.
School of Health in Social Science, University of Edinburgh, Edinburgh, UK.
Alzheimers Res Ther. 2022 Sep 30;14(1):142. doi: 10.1186/s13195-022-01082-9.
The individual and complementary value of the Visual Short-Term Memory Binding Test (VSTMBT) and the Free and Cued Selective Reminding Test (FCSRT) as markers to trace the AD continuum was investigated. It was hypothesised that the VSTMBT would be an early indicator while the FCSRT would inform on imminent progression.
Healthy older adults (n=70) and patients with mild cognitive impairment (MCI) (n=80) were recruited and followed up between 2012 and 2017. Participants with at least two assessment points entered the study. Using baseline and follow-up assessments four groups were defined: Older adults who were healthy (HOA), with very mild cognitive but not functional impairment (eMCI), and with MCI who did and did not convert to dementia (MCI converters and non-converters).
Only the VSTMBT predicted group membership in the very early stages (HOA vs eMCI). As the disease progressed, the FCSRT became a strong predictor excluding the VSTMB from the models. Their complementary value was high during the mid-prodromal stages and decreased in stages closer to dementia.
The study supports the notion that neuropsychological assessment for AD needs to abandon the notion of one-size-fits-all. A memory toolkit for AD needs to consider tools that are early indicators and tools that suggest imminent progression. The VSTMBT and the FSCRT are such tools.
本研究旨在探讨视觉短期记忆绑定测试（VSTMBT）和自由和线索选择性回忆测试（FCSRT）作为追踪 AD 连续体的标志物的个体和互补价值。研究假设 VSTMBT 将是早期指标，而 FCSRT 将提供即将进展的信息。
本研究纳入了 70 名健康老年人和 80 名轻度认知障碍（MCI）患者，并于 2012 年至 2017 年期间进行了随访。至少有两次评估点的参与者纳入了本研究。使用基线和随访评估，定义了四个组：健康的老年人（HOA）、有轻度认知但无功能障碍的老年人（eMCI）、有 MCI 且转换为痴呆的老年人（MCI 转换者）和未转换为痴呆的老年人（MCI 非转换者）。
仅 VSTMBT 可预测早期（HOA 与 eMCI）的分组。随着疾病的进展，FCSRT 成为一个强有力的预测因子，将 VSTMBT 排除在模型之外。在中前驱阶段，它们的互补价值较高，而在更接近痴呆的阶段则降低。
该研究支持了这样一种观点，即 AD 的神经心理学评估需要摒弃一刀切的观念。AD 的记忆工具包需要考虑早期指标工具和提示即将进展的工具。VSTMBT 和 FSCRT 就是这样的工具。
