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认知储备如何促进认知和神经行为健康?

How Can Cognitive Reserve Promote Cognitive and Neurobehavioral Health?

机构信息

Cognitive Neuroscience Division, Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.

出版信息

Arch Clin Neuropsychol. 2021 Oct 13;36(7):1291-1295. doi: 10.1093/arclin/acab049.

Abstract

OBJECTIVE

This review is aimed at understanding how cognitive reserve and related concepts contribute to promoting neurobehavioral and cognitive health, consistent with goal of the 2020 national academy of neuropsychology (NAN) Annual Meeting.Research indicates that lifestyle factors such as achieving educational and work milestones, participating in leisure and social activities and IQ are all associated with reduced risk of cognitive decline in normal aging and of developing dementia. Many of these lifestyle factors have also been associated with better cognition in other psychiatric and neurological conditions. The cognitive reserve hypothesis posits that these lifestyle factors result in individual differences in the flexibility and adaptability of brain networks that may allow some people to cope better than others with age- or dementia-related brain changes. Recent evidence also supports the idea that specific genetic and lifestyle factors may help preserve a healthy brain or enhance brain reserve, a process that has been called brain maintenance. The complementary concept of brain reserve posits that structural brain features can guard against dementia and related conditions. This review defines these theoretical concepts, their research basis, how they are studied and their clinical applications.

CONCLUSION

Evidence supports the concept of reserve, which can be influenced by experiences in every stage of life. Focused research in this area can maximize the chance for successful intervention.

摘要

目的

本综述旨在了解认知储备和相关概念如何有助于促进神经行为和认知健康,这符合 2020 年国家神经心理学会(NAN)年会的目标。研究表明,生活方式因素,如实现教育和工作目标、参与休闲和社会活动以及智商,都与正常衰老时认知能力下降和痴呆风险降低有关。许多这些生活方式因素也与其他精神和神经疾病中更好的认知有关。认知储备假说假设,这些生活方式因素导致大脑网络的灵活性和适应性存在个体差异,这可能使一些人比其他人更好地应对与年龄或痴呆相关的大脑变化。最近的证据也支持这样一种观点,即特定的遗传和生活方式因素可能有助于保持大脑健康或增强大脑储备,这一过程被称为大脑维持。大脑储备的补充概念假设,结构大脑特征可以预防痴呆和相关疾病。本综述定义了这些理论概念、它们的研究基础、研究方法及其临床应用。

结论

有证据支持储备的概念,而储备可以受到生命各个阶段经历的影响。在该领域的集中研究可以最大限度地提高成功干预的机会。

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