Agardh C D, Agardh E, Bauer B
Acta Ophthalmol (Copenh). 1987 Jun;65(3):358-62. doi: 10.1111/j.1755-3768.1987.tb08519.x.
The cause of retinopathy in diabetes mellitus is unknown. Among factors suggested to be involved in the development of retinopathy is altered platelet function. In the present study, platelet aggregation was measured in vitro after stimulation with adenosine diphosphate (ADP) and collagen in patients with and without proliferative retinopathy. The results show that patients with proliferative retinopathy have an increased platelet aggregation in vitro after stimulation with collagen and ADP. However, the increased platelet aggregation was also found to be correlated to the duration of diabetes. Thus, the present study does not support the opinion that abnormal platelet function can be regarded as a primary cause of diabetic retinopathy. Increased platelet aggregation seems to be coupled to the duration of diabetes and to still unknown factors developing with prolonged duration of the disease.
糖尿病性视网膜病变的病因尚不清楚。在被认为与视网膜病变发展有关的因素中，血小板功能改变是其中之一。在本研究中，对有和没有增殖性视网膜病变的患者，在二磷酸腺苷（ADP）和胶原蛋白刺激后，体外测量血小板聚集情况。结果显示，增殖性视网膜病变患者在胶原蛋白和ADP刺激后，体外血小板聚集增加。然而，血小板聚集增加也被发现与糖尿病病程相关。因此，本研究不支持将异常血小板功能视为糖尿病性视网膜病变主要病因的观点。血小板聚集增加似乎与糖尿病病程以及疾病长期发展中仍未知的因素有关。
