Watanabe J, Umeda F, Wakasugi H, Ibayashi H
Tohoku J Exp Med. 1984 Jun;143(2):161-9. doi: 10.1620/tjem.143.161.
Vitamin E is known to be an inhibitor of platelet prostaglandin production and aggregation. The rate of platelet aggregation induced by adenosine diphosphate was significantly increased in diabetics with proliferative retinopathy, and the enhanced production of thromboxane B2, a stable metabolite of thromboxane A2, was demonstrated in those patients. On the other hand, vitamin E was significantly reduced in platelets obtained from diabetics as compared to age matched control subjects. In addition, it was shown that vitamin E content in platelets examined in diabetic and control subjects inversely correlated with both the rate of platelet aggregation and thromboxane B2 production during aggregation. It is suggested that the reduced vitamin E levels in diabetic platelets can contribute to the mechanisms of the enhanced platelet thromboxane A2 production and aggregation which lead to the development of vascular complications.
众所周知，维生素E是血小板前列腺素生成和聚集的抑制剂。在患有增殖性视网膜病变的糖尿病患者中，由二磷酸腺苷诱导的血小板聚集率显著增加，并且在这些患者中证实了血栓素A2的稳定代谢产物血栓素B2的生成增强。另一方面，与年龄匹配的对照受试者相比，糖尿病患者血小板中的维生素E显著降低。此外，研究表明，糖尿病患者和对照受试者血小板中的维生素E含量与血小板聚集率以及聚集过程中血栓素B2的生成均呈负相关。提示糖尿病患者血小板中维生素E水平降低可能有助于增强血小板血栓素A2生成和聚集的机制，而这会导致血管并发症的发生。
