使用和不使用亮蓝G进行黄斑裂孔手术后的视网膜外层微观结构和视觉功能

Outer retinal microstructure and visual function after macular hole surgery with and without Brilliant Blue G.

作者信息

Komiya Yuko, Takeyama Asuka, Shibata Masaki, Imamura Yutaka, Ishida Masahiro

机构信息

Department of Ophthalmology, Teikyo University School of Medicine, University Hospital Mizonokuchi, 5-1-1, Futago, Takatsu-ku, Kawasaki, Kanagawa, 213-8507, Japan.

Department of Ophthalmology, Toho University Ohashi Medical Center, 2-22-36, Ohashi, Meguro-ku, Tokyo, 153-8515, Japan.

出版信息

Jpn J Ophthalmol. 2022 Nov;66(6):534-540. doi: 10.1007/s10384-022-00942-z. Epub 2022 Oct 1.

DOI:10.1007/s10384-022-00942-z

PMID:36181645

Abstract

PURPOSE

To evaluate the outer retinal microstructure and visual function after idiopathic macular hole (MH) surgery using internal limiting membrane (ILM) peeling with and without Brilliant Blue G (BBG) staining.

STUDY DESIGN

Retrospective, consecutive case series.

METHODS

A total of 49 eyes of 47 patients were enrolled: 23 eyes of 23 patients with MH who underwent ILM peeling without dyes (control group) and 26 eyes of 26 patients who underwent BBG staining (BBG group). The lengths of defects of the photoreceptor ellipsoid zone (EZ), external limiting membrane (ELM), and interdigitation zone (IZ) were measured.

RESULTS

The rate of MH closure after initial surgery was 95.6% (22/23 eyes) for the control group versus 100% (26/26 eyes) for the BBG group. In the 48 eyes with MH closure, the recovery rate of ELM deficiency and change in IZ deficiency showed no difference between the groups. The changes in EZ deficiency at 1 and 12 months were greater in the BBG group than in the control group. (P = 0.047 and 0.031). Visual acuity was better in the BBG group than in the control group during 12 months postoperatively (P < 0.001-0.038).

CONCLUSION

Eyes undergoing BBG-assisted MH surgery achieved faster recovery of the outer retinal structures and greater visual improvement than those of eyes without BBG.

摘要

目的

评估使用内界膜（ILM）剥除术且有或无亮蓝G（BBG）染色的特发性黄斑裂孔（MH）手术后的视网膜外层微观结构和视觉功能。

研究设计

回顾性连续病例系列。

方法

共纳入47例患者的49只眼：23例接受无染料ILM剥除术的MH患者的23只眼（对照组）和26例接受BBG染色的患者的26只眼（BBG组）。测量光感受器椭圆体带（EZ）、外界膜（ELM）和指状交叉带（IZ）的缺损长度。

结果

初始手术后，对照组MH闭合率为95.6%（22/23只眼），BBG组为100%（26/26只眼）。在48只MH闭合的眼中，两组间ELM缺损的恢复率和IZ缺损的变化无差异。BBG组在术后1个月和12个月时EZ缺损的变化大于对照组（P = 0.047和0.031）。术后12个月内，BBG组的视力优于对照组（P < 0.001 - 0.038）。