Selton J, Hubert I, Latarche C, Casillas-Gil M, Ouled-Moussa R, Berrod J-P
Service d'ophtalmologie A, CHU de Nancy, allée du Morvan, 54511 Vandœuvre-les-Nancy cedex, France.
J Fr Ophtalmol. 2012 Jun;35(6):397-401. doi: 10.1016/j.jfo.2011.08.015. Epub 2012 Apr 6.
To evaluate the role of Brilliant Blue G (BBG) in macular hole (MH) surgery.
Comparative retrospective study between two groups of 20 consecutive patients who underwent macular hole surgery. In the first group (G1), the inner limiting membrane (ILM) was systematically peeled without staining, while in the second group (G2), BBG was consistently utilized. Pre- and postoperative logMAR visual acuities (VA) were studied, as well as macular optical coherence tomography (OCT) scans to measure MH size, to confirm postoperative closure and to evaluate the integrity of the IS/OS junction. Time required and difficulty of peeling were compared between the two groups. Minimum follow-up was six months.
After six months follow-up, the average improvement in acuity was 0.56±0.48 logMAR for G1, versus 0.60±0.44 logMAR for G2 (P=0.80). The rate of closure after one surgery was 85% (17/20 patients) for G1, versus 95% (19/20 patients) for G2 (P=0.29). Postoperative OCT appearance of the IS/OS junction was similar in both groups: intact in 16/20 patients (80%), disrupted in 3/20 patients (15%), and indeterminate in 1/20 patients (5%) (P=1). The mean duration of peeling in G1 was 270.9±27.4 seconds. It was deemed difficult in ten eyes and incomplete in two patients, while in the G2 group, the mean duration of ILM peeling was 140.8±37.6 seconds (P<0.01); it was deemed complete and technically easy in all cases.
The use of BBG was effective in facilitating and accelerating ILM peeling during MH surgery. The anatomical and functional results were not statistically better in the group that received BBG.
评估亮蓝G（BBG）在黄斑裂孔（MH）手术中的作用。
对两组连续20例接受黄斑裂孔手术的患者进行比较回顾性研究。第一组（G1）系统地剥除内界膜（ILM）且不进行染色，而第二组（G2）持续使用BBG。研究术前和术后的logMAR视力（VA），以及黄斑光学相干断层扫描（OCT）以测量MH大小、确认术后闭合情况并评估IS/OS连接的完整性。比较两组之间所需的时间和剥除的难度。最短随访时间为6个月。
随访6个月后，G1组视力平均改善0.56±0.48 logMAR，G2组为0.60±0.44 logMAR（P = 0.80）。一次手术后G1组的闭合率为85%（17/20例患者），G2组为95%（19/20例患者）（P = 0.29）。两组术后OCT显示的IS/OS连接情况相似：16/20例患者（80%）完整，3/20例患者（15%）中断，1/20例患者（5%）不确定（P = 1）。G1组剥除的平均持续时间为270.9±27.4秒。10只眼中认为操作困难，2例患者操作不完全，而在G2组，ILM剥除的平均持续时间为140.8±37.6秒（P<0.01）；所有病例均认为操作完整且技术上容易。
在MH手术中使用BBG可有效促进和加速ILM剥除。接受BBG的组在解剖和功能结果上在统计学上并无更好表现。
