Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, China; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China.
Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, China.
Eur J Pharmacol. 2022 Nov 5;934:175299. doi: 10.1016/j.ejphar.2022.175299. Epub 2022 Sep 29.
Cataract is the leading cause of blindness worldwide. Cataract phacoemulsification combined with intraocular lens implantation causes great burden to global healthcare, especially for low- and middle-income countries. Such burden would be significantly relieved if cataracts can effectively be treated or delayed by non-surgical means. Excitingly, novel drugs have been developed to treat cataracts in recent decades. For example, oxysterols are found to be able to innovatively reverse lens clouding, novel nanotechnology-loaded drugs improve anti-cataract pharmacological effect, and traditional Chinese medicine demonstrates promising therapeutic effects against cataracts. In the present review, we performed bibliometric analysis to provide an overview perspective regarding the research status, hot topics, and academic trends in the field of anti-cataract pharmacology therapy. We further reviewed the curative effects and molecular mechanisms of anti-cataract drugs such as lanosterol, metformin, resveratrol and curcumin, and prospected the possibility of their clinical application in future.
白内障是全球致盲的主要原因。白内障超声乳化联合人工晶状体植入术给全球医疗保健带来了巨大负担，尤其是对中低收入国家而言。如果能通过非手术手段有效治疗或延缓白内障，这种负担将大大减轻。令人兴奋的是，近几十年来已经开发出了一些治疗白内障的新药。例如，发现氧化固醇能够创新性地逆转晶状体混浊，新型载药纳米技术可提高抗白内障药理作用，而中药对白内障也显示出有希望的治疗效果。在本综述中，我们进行了文献计量分析，提供了抗白内障药理学治疗领域的研究现状、热点和学术趋势的概述。我们进一步综述了羊毛甾醇、二甲双胍、白藜芦醇和姜黄素等抗白内障药物的疗效和分子机制，并展望了它们在未来临床应用的可能性。
