稠李甾醇 A-D，从樗树叶中分离得到的四个新甾体。
Chouchunsteride A-D, four new steroids from the leaves of Ailanthus altissima (Mill.) Swingle.
机构信息
Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.
Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.
出版信息
Steroids. 2022 Dec;188:109117. doi: 10.1016/j.steroids.2022.109117. Epub 2022 Sep 29.
Four new steroids, chouchunsteride A-D (1-4), together with four known steroids (5-8), were isolated from the leaves of Ailanthus altissima (Mill.) Swingle. Their structures were elucidated based on spectroscopic data analysis, while the relative and absolute configurations were determined via acetonide analysis and quantum chemical ECD calculations. All isolated steroids were evaluated for their cytotoxic activity against two hepatoma carcinoma cell lines (HepG2, Hep3B). Among them, 1 exhibited the most potent cytotoxicity against HepG2 cells with an IC value of 4.03 μM.
从臭椿（Ailanthus altissima（Mill.）Swingle）的叶子中分离得到了 4 个新甾体化合物，chouchunsteride A-D（1-4），以及 4 个已知甾体化合物（5-8）。基于光谱数据分析确定了它们的结构，而通过乙酰化分析和量子化学 ECD 计算确定了它们的相对和绝对构型。所有分离得到的甾体化合物均对两种肝癌细胞系（HepG2、Hep3B）进行了细胞毒性评价。其中，1 对 HepG2 细胞表现出最强的细胞毒性，IC 值为 4.03 μM。
Zotero 插件