从臭椿（Ailanthus altissima （Mill.）Swingle）根皮中提取的萜烯化香豆素。
Terpenylated coumarins from the root bark of Ailanthus altissima (Mill.) Swingle.
机构信息
School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
出版信息
Phytochemistry. 2020 Jul;175:112361. doi: 10.1016/j.phytochem.2020.112361. Epub 2020 Apr 11.
Seven undescribed terpenylated coumarins, named altissimacoumarin I-O, together with seven known compounds, altissimacoumarin C, altissimacoumarin E, altissimacoumarin G, altissimacoumarin H, puberulin, 7-(3-Methyl-2-butenyloxy)-6-methoxycoumarin and artelin were isolated from the root bark of Ailanthus altissima (Mill.) Swingle. Their structures were elucidated by comprehensive spectra data analysis, NMR calculation, DP4+ analysis and ACD/Structure Elucidator software simulation. The absolute configurations of altissimacoumarins K, L, M and N were determined by modified Mosher's method. All isolates were tested for their cytotoxic effect against two hepatoma carcinoma cell lines (HepG2, Hep3B). Altissimacoumarin C exhibited moderate cytotoxic effect against Hep3B cells, with IC of 45.21 μM.
从臭椿（Ailanthus altissima（Mill.）Swingle）的根皮中分离得到了 7 种未描述的萜类香豆素，分别命名为 altissimacoumarin I-O，以及 7 种已知化合物，altissimacoumarin C、altissimacoumarin E、altissimacoumarin G、altissimacoumarin H、puberulin、7-(3-甲基-2-丁烯氧基)-6-甲氧基香豆素和 artelin。通过综合光谱数据分析、NMR 计算、DP4+分析和 ACD/Structure Elucidator 软件模拟，确定了它们的结构。通过改进的 Mosher 法确定了 altissimacoumarin K、L、M 和 N 的绝对构型。所有分离物均测试了对两种肝癌细胞系（HepG2、Hep3B）的细胞毒性。Altissimacoumarin C 对 Hep3B 细胞表现出中等的细胞毒性，IC 为 45.21 μM。
Zotero 插件