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明智选择:关于病毒性肝炎治疗中应避免的五大操作的建议:巴西肝病学会立场声明,经拉丁美洲肝脏研究协会认可

Choosing wisely recommendations regarding the top five list of procedures to avoid in the treatment of viral hepatitis: A position statement from the Brazilian Society of Hepatology endorsed by the Latin American Association for the Study of the liver.

作者信息

Villela-Nogueira Cristiane A, Ferraz Maria Lúcia Gomes, Pessoa Mário Guimarães, Souto Francisco José Dutra, Nabuco Letícia Cancella, Coelho Henrique Sérgio Moraes, Ridruejo Ezequiel, Silva Marcelo, Bittencourt Paulo Lisboa, Brandão-Mello Carlos Eduardo

机构信息

Faculdade de Medicina, Departamento de Clínica Médica e Serviço de Hepatologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Brazil.

Disciplina de Gastroenterologia, Universidade Federal de São Paulo, Brazil.

出版信息

Ann Hepatol. 2023 Jan-Feb;28(1):100764. doi: 10.1016/j.aohep.2022.100764. Epub 2022 Sep 28.

Abstract

INTRODUCTION AND OBJECTIVES

The Choosing Wisely (CW) initiative aims to improve daily practice supported by evidence concerning unnecessary medical tests, procedures, and treatments. This philosophy is essential in managing viral hepatitis (VH), which primary care physicians increasingly carry out. It is also essential to achieving disease elimination. Thus, the aim of our study was to propose evidence-based CW recommendations in VH.

MATERIALS AND METHODS

The Brazilian Society of Hepatology (SBH) formed a panel of experts in VH who selected evidence-based CW recommendations, which were subsequently scrutinized and ranked by all members of SBH using a web-based approach.

RESULTS

Five recommendations were chosen in order of importance: 1) do not order anti-HCV testing after achieving sustained virological response; 2) do not request serial HCV viral load to evaluate HCV progression, 3) do not add ribavirin to direct-acting antivirals in non-cirrhotic, naïve HCV patients; 4) do not screen for hepatocellular carcinoma in HCV patients with none to moderate fibrosis (≤ F2); 5) do not request anti-HBs after HBV vaccination, except for children born to HBV-infected mothers, hemodialysis patients, healthcare professionals, people who have had sexual contact with chronic HBV carriers, HIV-positive persons and immunocompromised individuals (hematopoietic stem-cell transplant recipients or persons receiving chemotherapy).

CONCLUSIONS

CW recommendations may help general practitioners adopt a more rational and cost-effective approach in managing patients with VH in Brazil and Latin America, leading to lesser waste or harm to patients.

摘要

引言与目标

明智选择(CW)倡议旨在改进日常医疗实践,其依据是关于不必要的医学检查、程序和治疗的证据。这种理念在管理病毒性肝炎(VH)方面至关重要,因为基层医疗医生越来越多地参与其中。这对于实现疾病消除也至关重要。因此,我们研究的目的是提出基于证据的病毒性肝炎明智选择建议。

材料与方法

巴西肝病学会(SBH)组建了一个病毒性肝炎专家小组,该小组挑选了基于证据的明智选择建议,随后由SBH的所有成员通过基于网络的方法对这些建议进行审查和排序。

结果

按重要性顺序选出了五条建议:1)在实现持续病毒学应答后不要进行抗-HCV检测;2)不要要求进行连续的HCV病毒载量检测以评估HCV进展;3)在无肝硬化的初治HCV患者中,不要在直接作用抗病毒药物基础上加用利巴韦林;4)对于纤维化程度为无至中度(≤F2)的HCV患者,不要进行肝细胞癌筛查;5)除了HBV感染母亲所生的儿童、血液透析患者、医护人员、与慢性HBV携带者有性接触者、HIV阳性者和免疫功能低下者(造血干细胞移植受者或接受化疗者)外,HBV疫苗接种后不要检测抗-HBs。

结论

明智选择建议可能有助于巴西和拉丁美洲的全科医生在管理病毒性肝炎患者时采用更合理且具成本效益的方法,从而减少对患者的浪费或伤害。

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