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Isocapnic CO2 administration stabilizes breathing and eliminates apneas during sleep in obese mice exposed to hypoxia.

作者信息

Kim Lenise J, Pho Huy, Pham Luu V, Polotsky Vsevolod Y

机构信息

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

出版信息

Sleep. 2023 Feb 8;46(2). doi: 10.1093/sleep/zsac243.

DOI:10.1093/sleep/zsac243
PMID:36183293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9905775/
Abstract
摘要

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Isocapnic CO2 administration stabilizes breathing and eliminates apneas during sleep in obese mice exposed to hypoxia.在暴露于低氧环境的肥胖小鼠中，等碳酸血症性二氧化碳给药可稳定呼吸并消除睡眠期间的呼吸暂停。
Sleep. 2023 Feb 8;46(2). doi: 10.1093/sleep/zsac243.
2
Effects of inhaled CO2 and added dead space on idiopathic central sleep apnea.吸入二氧化碳和增加无效腔对特发性中枢性睡眠呼吸暂停的影响。
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Obesity accentuates circadian variability in breathing during sleep in mice but does not predispose to apnea.肥胖症会加重小鼠睡眠期间呼吸的昼夜变化，但不会导致呼吸暂停。
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Mechanisms of hypoxia-induced periodic breathing during sleep in humans.人类睡眠期间缺氧诱导周期性呼吸的机制。
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Dependence of high altitude sleep apnea on ventilatory sensitivity to hypoxia.高原睡眠呼吸暂停对低氧通气敏感性的依赖性。
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Sleep apnea considered as a control system instability.睡眠呼吸暂停被认为是一种控制系统不稳定的情况。
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Central sleep apnea.中枢性睡眠呼吸暂停
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Effects of inspired gas on sleep-related apnea in the rat.吸入气体对大鼠睡眠相关呼吸暂停的影响。
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Measurement of gastric P(CO2) as an index of tissue hypoxia during obstructive sleep apnea.
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Effect of ventilatory drive on carbon dioxide sensitivity below eupnea during sleep.睡眠期间通气驱动对低于平静呼吸时二氧化碳敏感性的影响。
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How far would you go to sleep better at high altitude?为了在高海拔地区睡得更好，你会做到什么程度？
Sleep. 2023 Feb 8;46(2). doi: 10.1093/sleep/zsac277.

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Risk factors for acute mountain sickness in travellers to Cusco, Peru: coca leaves, obesity and sex.前往秘鲁库斯科的旅行者中急性高原病的危险因素：古柯叶、肥胖和性别。
J Travel Med. 2022 Aug 20;29(5). doi: 10.1093/jtm/taab102.
2
Acute Altitude Acclimatization in Young Healthy Volunteers: Nocturnal Oxygenation Increases Over Time, Whereas Periodic Breathing Persists.年轻健康志愿者的急性高原适应：夜间氧合随时间增加，而周期性呼吸持续存在。
High Alt Med Biol. 2021 Mar;22(1):14-23. doi: 10.1089/ham.2020.0009. Epub 2020 Nov 12.
3
Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response.瘦素在颈动脉体中发挥作用，增加觉醒和睡眠时的分钟通气量，并增强低氧通气反应。
J Physiol. 2019 Jan;597(1):151-172. doi: 10.1113/JP276900. Epub 2018 Nov 29.
4
Sleep-disordered breathing in C57BL/6J mice with diet-induced obesity.饮食诱导肥胖 C57BL/6J 小鼠的睡眠呼吸紊乱。
Sleep. 2018 Aug 1;41(8). doi: 10.1093/sleep/zsy089.
5
Cross-Sectional Comparison of Sleep-Disordered Breathing in Native Peruvian Highlanders and Lowlanders.秘鲁本土高地人和低地人睡眠呼吸障碍的横断面比较
High Alt Med Biol. 2017 Mar;18(1):11-19. doi: 10.1089/ham.2016.0102.
6
Central sleep apnea.中枢性睡眠呼吸暂停。
Compr Physiol. 2013 Jan;3(1):141-63. doi: 10.1002/cphy.c110057.
7
Real-time dynamic carbon dioxide administration: a novel treatment strategy for stabilization of periodic breathing with potential application to central sleep apnea.实时动态二氧化碳管理：一种稳定周期性呼吸的新型治疗策略，可能适用于中枢性睡眠呼吸暂停。
J Am Coll Cardiol. 2010 Nov 23;56(22):1832-7. doi: 10.1016/j.jacc.2010.05.053.
8
Exacerbation of sleep apnoea by frequent central events in patients with the obstructive sleep apnoea syndrome at altitude: a randomised trial.高海拔地区阻塞性睡眠呼吸暂停综合征患者频繁中枢事件致睡眠呼吸暂停恶化：一项随机试验。
Thorax. 2010 May;65(5):429-35. doi: 10.1136/thx.2009.125849.
9
Hypocapnia decreases the amount of rapid eye movement sleep in cats.低碳酸血症会减少猫的快速眼动睡眠时间。
Sleep. 2003 Dec 15;26(8):961-7. doi: 10.1093/sleep/26.8.961.
10
Effect of hypoxia on the hypopnoeic and apnoeic threshold for CO(2) in sleeping humans.低氧对睡眠中人类二氧化碳低通气阈值和呼吸暂停阈值的影响。
J Physiol. 2001 Aug 15;535(Pt 1):269-78. doi: 10.1111/j.1469-7793.2001.00269.x.