Gu Xiaolin, Li Tingting, Si Junzeng, Gao Longfei, Li Yan, Qi Aiqin
Department of Neurology, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan 271100, China.
Evid Based Complement Alternat Med. 2022 Sep 22;2022:4661687. doi: 10.1155/2022/4661687. eCollection 2022.
To investigate the changes in the levels of homocysteine (Hcy) and C-reactive protein (CRP) in patients with Alzheimer's disease (AD) and analyze their correlation with cognitive and UPDRS functions.
A total of 50 patients with AD admitted to our hospital from January 2020 to March 2022 were selected into the research group, and 50 healthy subjects were selected as the control group. The levels of Hcy and CRP of the two groups were analyzed, and the patients' cognitive functions were evaluated with the Mini-Mental State Examination (MMSE) score and UPDRS function scoring. The correlation between the changes in levels of Hcy and CRP, and cognitive and UPDRS functions in the two groups was compared and analyzed.
The levels of Hcy and CRP of the research group were higher than those of the control group, with statistical significance ( < 0.05). The following were evaluated for the scoring of patients' cognitive functions in the research group: orientation, attentional computation, short-term memory, language ability, visuospatial ability, instant memory, and MMSE total score, all of which were lower than those in the control group, with statistical significance ( < 0.05). UPDRS I, UPDRS, UPDRS, and total UPDRS score in the research group were higher than those in the control group, with statistical significance ( < 0.05). In the research group, the higher the Hcy level, the lower the MMSE score, with a negative correlation ( < 0.05), and the higher the Hcy level, the higher the UPDRS score, with a positive correlation ( < 0.05). And, the higher the CRP level, the lower the MMSE score, with a negative correlation ( < 0.05); the higher the CRP level, the higher the UPDRS score, with a positive correlation ( < 0.05).
Compared with the health subject group, the levels of Hcy and CRP were higher in patients with AD, and their changes had a negative correlation with cognitive functions in patients with AD, and a positive correlation with UPDRS in patients with AD, with high clinical values in evaluating cognitive and UPDRS functions.
探讨阿尔茨海默病（AD）患者同型半胱氨酸（Hcy）和C反应蛋白（CRP）水平的变化，并分析其与认知功能及统一帕金森病评定量表（UPDRS）功能的相关性。
选取2020年1月至2022年3月我院收治的50例AD患者作为研究组，选取50例健康受试者作为对照组。分析两组的Hcy和CRP水平，采用简易精神状态检查表（MMSE）评分和UPDRS功能评分评估患者的认知功能。比较并分析两组中Hcy和CRP水平变化与认知功能及UPDRS功能之间的相关性。
研究组的Hcy和CRP水平高于对照组，差异有统计学意义（<0.05）。对研究组患者的认知功能评分进行如下评估：定向力、注意力计算、短期记忆、语言能力、视觉空间能力、即刻记忆及MMSE总分，均低于对照组，差异有统计学意义（<0.05）。研究组的UPDRS I、UPDRSⅡ、UPDRSⅢ及UPDRS总分均高于对照组，差异有统计学意义（<0.05）。在研究组中，Hcy水平越高，MMSE评分越低，呈负相关（<0.05）；Hcy水平越高，UPDRS评分越高，呈正相关（<0.05）。并且，CRP水平越高，MMSE评分越低，呈负相关（<0.05）；CRP水平越高，UPDRS评分越高，呈正相关（<0.05）。
与健康受试者组相比，AD患者的Hcy和CRP水平更高，其变化与AD患者的认知功能呈负相关，与AD患者的UPDRS呈正相关，在评估认知功能和UPDRS功能方面具有较高的临床价值。
