Department of Neurology, Ningbo First Hospital, Ningbo, ZheJiang, China.
Department of Neurology, Ningbo Municipal Hospital of TCM, Ningbo, ZheJiang, China.
Brain Behav. 2020 Dec;10(12):e01893. doi: 10.1002/brb3.1893. Epub 2020 Oct 16.
There have been studies investigating sex differences in clinical manifestation of Parkinson's disease (PD). However, sex differences in underweight and body mass index (BMI) in de novo PD patients lacked systematic study. We aimed to compare sex differences in clinical features and related factors of underweight and BMI in Chinese de novo PD patients.
A total of 253 untreated PD inpatients and 218 controls were recruited from Ningbo. BMI, demographics, Montreal Cognitive Assessment (MoCA), supine and upright blood pressure, Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), homocysteine (HCY), uric acid, glycated hemoglobin, and lipid parameters were examined. Patients were assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) motor scores and Hoehn and Yahr (HY) Rating Scale.
Female patients had a significantly lower incidence of underweight and higher BMI than male patients, and there were sex differences in serum lipids, HCY levels, and depression severity. Binary regression analysis showed that only in male patients was underweight associated with the UPDRS motor score and lower ΔSBP and ΔDBP values (all p < .05). Further multiple regression analysis indicated, in addition to the correlations between BMI and ΔSBP and ΔDBP values in both sexes (all p < .001), BMI was also associated with MoCA and lower UPDRS motor scores in male patients and lower HAMD scores in female patients.
Our study suggests that there are significant sex differences in the prevalence of underweight, BMI, and factors associated with underweight and BMI among de novo PD patients.
已有研究调查了帕金森病（PD）临床表现中的性别差异。然而，在新发 PD 患者中，体重不足和体重指数（BMI）的性别差异缺乏系统研究。我们旨在比较中国新发 PD 患者中体重不足和 BMI 的临床特征和相关因素的性别差异。
共招募了 253 名未经治疗的 PD 住院患者和 218 名对照者，他们来自宁波。检查了 BMI、人口统计学数据、蒙特利尔认知评估（MoCA）、仰卧位和直立位血压、汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）、同型半胱氨酸（HCY）、尿酸、糖化血红蛋白和血脂参数。使用统一帕金森病评定量表（UPDRS）运动评分和 Hoehn 和 Yahr（HY）评分对患者进行评估。
女性患者体重不足的发生率明显低于男性患者，BMI 较高，且血脂、HCY 水平和抑郁严重程度存在性别差异。二元回归分析显示，只有男性患者的体重不足与 UPDRS 运动评分以及较低的 ΔSBP 和 ΔDBP 值相关（均 p<.05）。进一步的多元回归分析表明，除了男女两性 BMI 与 ΔSBP 和 ΔDBP 值之间的相关性（均 p<.001）外，BMI 还与男性患者的 MoCA 和较低的 UPDRS 运动评分以及女性患者的 HAMD 评分相关。
我们的研究表明，新发 PD 患者中体重不足、BMI 以及与体重不足和 BMI 相关的因素的发生率存在显著的性别差异。
