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BUB1B/hsa-miR-130a-3p轴的泛癌分析以及循环hsa-miR-130a-3p作为癌症风险评估潜在生物标志物的鉴定

Pan-Cancer Analysis of BUB1B/hsa-miR-130a-3p Axis and Identification of Circulating hsa-miR-130a-3p as a Potential Biomarker for Cancer Risk Assessment.

作者信息

Ding Xiaoxia, Chen Lele, Xu Danfeng, Yu Yong, Tao Xiaohua, Fan Yibin, Huang Youming

机构信息

Health Management Center, Department of Dermatology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Department of Dermatology and Venereology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.

出版信息

Evid Based Complement Alternat Med. 2022 Sep 22;2022:3261300. doi: 10.1155/2022/3261300. eCollection 2022.

DOI:10.1155/2022/3261300
PMID:36185088
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9522491/
Abstract

Based on the fact that very little was found in the literature on the question of potential molecules and mechanism for high risk of cancer in patients with psoriasis, this study was designed and performed based on bioinformatics analysis including WGCNA. The most striking result to emerge from the data is that BUB1B/hsa-miR-130a-3p axis, closely related to the development of psoriasis, also plays a remarkable role in multiple cancer development. The expression patterns of hsa-miR-130a-3p were found significantly changed in multiple tumors, which was also associated with prognosis. Additionally, hsa-miR-130a-3p was downregulated in lesion skin of psoriasis, but there was no difference in blood between psoriasis patients and normal controls. Circulating has-miR-130a-3p was found to have a higher level of blood in multiple tumor patients, suggesting that hsa-miR-130a-3p has the potential to be a blood biomarker for cancer risk assessment in patients with psoriasis.

摘要

基于在文献中很少发现关于银屑病患者癌症高风险的潜在分子和机制问题，本研究基于包括加权基因共表达网络分析（WGCNA）在内的生物信息学分析进行设计和实施。数据中最显著的结果是，与银屑病发展密切相关的BUB1B/hsa-miR-130a-3p轴在多种癌症发展中也起着显著作用。发现hsa-miR-130a-3p的表达模式在多种肿瘤中显著改变，这也与预后相关。此外，hsa-miR-130a-3p在银屑病皮损中表达下调，但银屑病患者与正常对照者血液中无差异。发现循环中的hsa-miR-130a-3p在多种肿瘤患者血液中的水平较高，这表明hsa-miR-130a-3p有可能成为银屑病患者癌症风险评估的血液生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1083/9522491/5839f630163e/ECAM2022-3261300.011.jpg
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